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Abstract：
Complex cannibalism (CxC) is an emerging new seeming entity in oral squamous cell carcinoma (OSCC) embody as a prime metabolic event in determining the aggressive potential. Owing to paucity in literature regarding it, the aim of the present study to deciphering the occurrence of CxC in OSCC. Further, the expression of cluster of differentiation 68 (CD68) was studied in tumor cells and correlated with CxC to ascertain the biological behaviour of OSCC. 30 Hematoxylin and Eosin stained sections of various grades of OSCC were scanned for CxC and correlated with clinicopathological parameters. Immunohistochemical analysis using CD68 was performed. While observing CxC in OSCC, statistically significant in age (p-0.048) and histological grades (p-0.004). CD68 expression in tumor cells was statistically significant in histopathological grades (p < 0.001) whereas on correlating with CxC (p - 0.171) was non-significant. The analogous rise in CxC and CD68 with increasing histopathological grades could aid in recognising CxC as a precise histopathological parameter to assess the aggressive biological potential in OSCC.
摘要：
复杂的同类相食（CxC）是口腔鳞状细胞癌（OSCC）中新兴的新实体，是确定其侵袭潜力的主要代谢事件。由于这方面的文献匮乏，本研究的目的是破译CxC在OSCC中的发生。Further,研究了分化簇68（CD68）在肿瘤细胞中的表达，并与CxC相关，以确定OSCC的生物学行为。对不同等级OSCC的苏木精和伊红染色切片进行CxC扫描,并与临床病理参数相关联。使用CD68进行免疫组织化学分析。在OSCC中观察CxC时，年龄（p-0.048）和组织学分级（p-0.004）具有统计学意义。肿瘤细胞中的CD68表达在组织病理学分级中具有统计学意义(p<0.001),而在与CxC相关时(p-0.171)则无统计学意义。随着组织病理学等级的增加，CxC和CD68的类似升高可能有助于将CxC识别为精确的组织病理学参数，以评估OSCC的侵袭性生物学潜力。
