PDF(Pubmed)
Abstract：
The role of estradiol (E2; an estrogen) in men needs to be more appreciated. In this review, we address the clinical situations that allow the study of the clinical consequences of E2 deficiency in men and discuss the effects of restoration of levels of this reproductive steroid hormone. In men with advanced prostate cancer (PCa) undergoing androgen deprivation therapy (ADT), E2 is suppressed along with testosterone, leading to side effects affecting the quality of life. These include hot flashes, arthralgia, fatigue, mood changes, cognition problems, weight gain, bone loss, and increased risk of cardiovascular disease. Transdermal E2 alone for ADT has shown equivalent testosterone suppression compared to gonadotropin-releasing hormone (GnRH) agonists while also preventing estrogen-deficiency side effects, including hot flashes and bone loss. Co-treatment of ADT with fetal estrogen estetrol (E4) has shown significant improvements of estrogen-deficiency symptoms. These observations emphasize the need to raise awareness of the importance of estrogens in men among clinicians and the lay public.
摘要：
雌二醇（E2;雌激素）在男性中的作用需要得到更多的重视。在这次审查中,我们讨论了允许研究男性E2缺乏的临床后果的临床情况，并讨论了恢复这种生殖类固醇激素水平的影响。在接受雄激素剥夺治疗（ADT）的晚期前列腺癌（PCa）男性中，E2与睾酮一起被抑制，导致影响生活质量的副作用。这些包括潮热，关节痛,疲劳,情绪变化,认知问题，体重增加,骨丢失,和心血管疾病的风险增加。与促性腺激素释放激素（GnRH）激动剂相比，单独用于ADT的E2已显示出等效的睾酮抑制，同时还可以预防雌激素缺乏的副作用。包括潮热和骨质流失.ADT与胎儿雌激素雌四醇（E4）的共同治疗已显示出雌激素缺乏症状的显着改善。这些观察结果强调，有必要提高临床医生和非专业人士对男性雌激素重要性的认识。
