PDF(Pubmed)
Abstract：
BACKGROUND: The purpose of this study was to identify the angiotensin-converting enzyme (ACE) gene (I/D) variations in CAD patients and healthy controls in an Iranian population (West Azerbaijan province of Iran).
METHODS: This cross-sectional study included 95 CAD patients and 203 healthy controls. ACE I/D polymorphisms were assessed using PCR, and their frequency was determined.
RESULTS: There were 298 people, 95 CAD patients, and 203 controls, with an average age of 50.96±3.45 and 51.14±10.20. We discovered that the frequency of the D allele was significantly higher in CAD patients than in controls (P = 0.0009). In contrast, the frequency of the I allele was significantly higher in controls than in CAD patients (P = 0.0009). The D allele carriers genotypes (DD + ID) were more frequent in the CAD patients than in the control group (P = 0.008). The ACE II genotype-state carriers were more common in the control group than in CAD patients (P = 0.008). However, in the case of the ACE ID genotype, no significant differences were not found in the tested groups (P = 0.47).
CONCLUSIONS: These findings suggest that individuals with the ACE DD genotype are predisposed to CAD, whereas individuals with the ACE II genotype state are protected.
METHODS: This cross-sectional study included 95 CAD patients and 203 healthy controls. ACE I/D polymorphisms were assessed using PCR, and their frequency was determined.
RESULTS: There were 298 people, 95 CAD patients, and 203 controls, with an average age of 50.96±3.45 and 51.14±10.20. We discovered that the frequency of the D allele was significantly higher in CAD patients than in controls (P = 0.0009). In contrast, the frequency of the I allele was significantly higher in controls than in CAD patients (P = 0.0009). The D allele carriers genotypes (DD + ID) were more frequent in the CAD patients than in the control group (P = 0.008). The ACE II genotype-state carriers were more common in the control group than in CAD patients (P = 0.008). However, in the case of the ACE ID genotype, no significant differences were not found in the tested groups (P = 0.47).
CONCLUSIONS: These findings suggest that individuals with the ACE DD genotype are predisposed to CAD, whereas individuals with the ACE II genotype state are protected.
摘要：
背景：这项研究的目的是确定伊朗人群（伊朗西阿塞拜疆省）中CAD患者和健康对照者的血管紧张素转换酶（ACE）基因（I/D）变异。
方法：这项横断面研究包括95名CAD患者和203名健康对照。使用PCR评估ACEI/D多态性，并确定了它们的频率。
结果：有298人，95名CAD患者，和203个控件，平均年龄50.96±3.45和51.14±10.20。我们发现CAD患者的D等位基因频率明显高于对照组（P=0.0009）。相比之下,对照组中I等位基因的频率显著高于CAD患者(P=0.0009).CAD患者中D等位基因携带者基因型（DDID）的频率高于对照组（P=0.008）。ACEII基因型状态携带者在对照组中比在CAD患者中更常见(P=0.008)。然而,在ACEID基因型的情况下，试验组中无显著差异(P=0.47).
结论：这些发现表明ACEDD基因型的个体易患CAD，而具有ACEII基因型状态的个体受到保护。
方法：这项横断面研究包括95名CAD患者和203名健康对照。使用PCR评估ACEI/D多态性，并确定了它们的频率。
结果：有298人，95名CAD患者，和203个控件，平均年龄50.96±3.45和51.14±10.20。我们发现CAD患者的D等位基因频率明显高于对照组（P=0.0009）。相比之下,对照组中I等位基因的频率显著高于CAD患者(P=0.0009).CAD患者中D等位基因携带者基因型（DDID）的频率高于对照组（P=0.008）。ACEII基因型状态携带者在对照组中比在CAD患者中更常见(P=0.008)。然而,在ACEID基因型的情况下，试验组中无显著差异(P=0.47).
结论：这些发现表明ACEDD基因型的个体易患CAD，而具有ACEII基因型状态的个体受到保护。
