PDF(Pubmed)
Abstract：
Treatments for articular cartilage injuries are still challenging, due in part to its avascular and aneural surroundings. Since the first report of autologous chondrocyte implantation, cell-based therapies have been extensively studied with a variety of cell sources, including chondrocytes and mesenchymal stem/stromal cells (MSCs). Recently, MSC-based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation. Using such cells, we have originally developed a 3-dimensional scaffold-free tissue-engineered construct (TEC) through simple-cell culture methods and demonstrated its feasibility for cartilage repair and regeneration in the first-in-human clinical trial. This review summarizes our novel scaffold-free approaches to use MSC for the restoration of damaged articular cartilage, documenting the progression from basic to clinical studies.
摘要：
关节软骨损伤的治疗仍然具有挑战性，部分原因是其无血管和无神经环境。自从首次报道自体软骨细胞植入以来，基于细胞的疗法已经被广泛地研究了各种细胞来源，包括软骨细胞和间充质干细胞/基质细胞(MSC)。最近,基于MSC的治疗已经得到了相当多的研究关注，因为在组织收获处理相对容易，以及随后的细胞扩增和分化。使用这样的细胞，我们最初通过简单的细胞培养方法开发了一种无三维支架的组织工程构建体(TEC),并在首次人体临床试验中证明了其用于软骨修复和再生的可行性.这篇综述总结了我们使用MSC修复受损关节软骨的新型无支架方法。记录从基础到临床研究的进展。
