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Abstract：
OBJECTIVE: Chronic suppurative otitis media (CSOM) is a chronic inflammation of the mucoperiosteal lining of the middle ear cleft, presenting with recurrent ear discharge through a tympanic membrane perforation. The present study aims to assess the spectrum of bacterial infection among CSOM cases and detect the isolated organism\'s antibiotic sensitivity pattern.
METHODS: The prospective hospital-based observational study was conducted from June 2021 to June 2022 and included 94 CSOM cases. An aural swab of the ear discharge was collected from each patient under aseptic precautions. The swab was utilized for Gram\'s staining and the aerobic bacterial pathogen culture. The organisms isolated were tested for antibiotic sensitivity using the Kirby-Bauer disc diffusion method.
RESULTS: The most affected age group was the second decade of life (27.7%, n=26), with a male-to-female ratio of 1.35:1. The mean duration of ear discharge was 24.0±14.7 months, mostly mucoid ear discharge (39.4%, n=37). Among gram-positive bacteria, methicillin-resistant Staphylococcus aureus was isolated in 16 (17.0%) cases. Pseudomonas aeruginosa was the most isolated gram-negative bacteria strain in 26 (27.7%) cases. Cotrimoxazole (67.7%, n=21) had the highest sensitivity towards gram-positive bacteria isolates. Amongst gram-negative bacteria, amikacin and ciprofloxacin were the most sensitive, with 78.0% (n=39) susceptibility.
CONCLUSIONS: Evaluating the spectrum of infecting organisms of CSOM and their antibiotic sensitivity may help initiate prompt treatment with the appropriate antibiotic regimen, thereby preventing future complications.
METHODS: The prospective hospital-based observational study was conducted from June 2021 to June 2022 and included 94 CSOM cases. An aural swab of the ear discharge was collected from each patient under aseptic precautions. The swab was utilized for Gram\'s staining and the aerobic bacterial pathogen culture. The organisms isolated were tested for antibiotic sensitivity using the Kirby-Bauer disc diffusion method.
RESULTS: The most affected age group was the second decade of life (27.7%, n=26), with a male-to-female ratio of 1.35:1. The mean duration of ear discharge was 24.0±14.7 months, mostly mucoid ear discharge (39.4%, n=37). Among gram-positive bacteria, methicillin-resistant Staphylococcus aureus was isolated in 16 (17.0%) cases. Pseudomonas aeruginosa was the most isolated gram-negative bacteria strain in 26 (27.7%) cases. Cotrimoxazole (67.7%, n=21) had the highest sensitivity towards gram-positive bacteria isolates. Amongst gram-negative bacteria, amikacin and ciprofloxacin were the most sensitive, with 78.0% (n=39) susceptibility.
CONCLUSIONS: Evaluating the spectrum of infecting organisms of CSOM and their antibiotic sensitivity may help initiate prompt treatment with the appropriate antibiotic regimen, thereby preventing future complications.
摘要：
目的：慢性化脓性中耳炎（CSOM）是中耳裂隙粘膜骨膜衬里的慢性炎症，通过鼓膜穿孔表现为反复的耳部分泌物。本研究旨在评估CSOM病例中的细菌感染谱，并检测分离生物体的抗生素敏感性模式。
方法：前瞻性医院观察性研究于2021年6月至2022年6月进行，包括94例CSOM病例。在无菌预防措施下从每位患者收集耳部分泌物的耳部拭子。拭子用于革兰氏染色和需氧细菌病原体培养。使用Kirby-Bauer圆盘扩散方法测试分离的生物体的抗生素敏感性。
结果：受影响最大的年龄组是生命的第二个十年（27.7％，n=26),男女比例为1.35:1。耳放电的平均持续时间为24.0±14.7个月,主要是粘液样耳朵分泌物(39.4%，n=37）。在革兰氏阳性菌中,耐甲氧西林金黄色葡萄球菌16例(17.0%)。铜绿假单胞菌是26例（27.7％）中最分离的革兰氏阴性菌。复方新诺明（67.7%，n=21）对革兰氏阳性细菌分离株的敏感性最高。在革兰氏阴性细菌中，阿米卡星和环丙沙星最敏感，敏感性为78.0%(n=39)。
结论：评估CSOM的感染菌谱及其抗生素敏感性可能有助于采用适当的抗生素方案进行及时治疗，从而防止未来的并发症。
方法：前瞻性医院观察性研究于2021年6月至2022年6月进行，包括94例CSOM病例。在无菌预防措施下从每位患者收集耳部分泌物的耳部拭子。拭子用于革兰氏染色和需氧细菌病原体培养。使用Kirby-Bauer圆盘扩散方法测试分离的生物体的抗生素敏感性。
结果：受影响最大的年龄组是生命的第二个十年（27.7％，n=26),男女比例为1.35:1。耳放电的平均持续时间为24.0±14.7个月,主要是粘液样耳朵分泌物(39.4%，n=37）。在革兰氏阳性菌中,耐甲氧西林金黄色葡萄球菌16例(17.0%)。铜绿假单胞菌是26例（27.7％）中最分离的革兰氏阴性菌。复方新诺明（67.7%，n=21）对革兰氏阳性细菌分离株的敏感性最高。在革兰氏阴性细菌中，阿米卡星和环丙沙星最敏感，敏感性为78.0%(n=39)。
结论：评估CSOM的感染菌谱及其抗生素敏感性可能有助于采用适当的抗生素方案进行及时治疗，从而防止未来的并发症。
