PDF(Pubmed)
Abstract：
The clotting system has evolved as an adaptive mechanism to prevent blood loss during vascular damage. However, the intricate nature of the clotting cascade and the complexities of human life can sometimes lead to the unnatural activation of this delicate cascade. This can result in blood clot formation within the cardiovascular system, contributing to a wide range of pathological conditions. Abnormal intravascular coagulation most commonly occurs in the deep veins of the lower extremities, and can emboli to other organs, hence, it is termed \"venous thromboembolism\" (VTE). In this report, we introduce a challenging case of VTE that poses a dilemma for current medical management. The patient with possible protein S deficiency underwent various guideline-directed medical treatments, yet experienced recurrent VTE episodes, including deep vein thrombosis (DVT) and pulmonary embolism (PE), leading to hospital readmissions. This case report sheds light on our challenges in effectively treating VTE.
摘要：
凝血系统已经发展成为一种适应性机制，可以防止血管损伤期间的失血。然而,凝血级联的复杂性和人类生活的复杂性有时会导致这种微妙级联的非自然激活。这可能导致心血管系统内的血凝块形成，导致广泛的病理状况。异常血管内凝血最常见于下肢深静脉，并且可以栓塞到其他器官，因此，它被称为“静脉血栓栓塞”（VTE）。在这份报告中,我们介绍了一个具有挑战性的VTE案例，这给当前的医疗管理带来了困境。可能有蛋白S缺乏症的患者接受了各种指南指导的药物治疗，但经历了反复的VTE发作，包括深静脉血栓形成（DVT）和肺栓塞（PE），导致再次入院。此病例报告揭示了我们在有效治疗VTE方面的挑战。
