PDF(Pubmed)
Abstract：
UNASSIGNED: The synaptic contacts play an important role in central nervous system (CNS) functioning. Ultrastructural features of synapses in CNS are not studied in naphthalene neurotoxicity model.
UNASSIGNED: In the present work, transmission electron microscopy was used for studying the ultrastructural features of synapses in the hippocampus of Sprague Dawley rat brain, on subsequent exposure to naphthalene balls. The ultrastructural changes were observed for naphthalene low dose (200 mg), high dose (400 mg) after the treatment for 28 days, and post-delayed toxicity phase after 14 days in Sprague Dawley rats.
UNASSIGNED: In comparison with different groups of naphthalene exposure including control and satellite, axon degeneration, axonal demyelination and abnormal synapses was observed in high dose naphthalene administration group. In the post-delayed naphthalene toxicity group, degeneration of synaptic contacts was observed.
UNASSIGNED: This exploration of ultrastructural variations in the synapses of Hippocampus gives information that will be valued in naphthalene neurotoxicological research.
UNASSIGNED: In the present work, transmission electron microscopy was used for studying the ultrastructural features of synapses in the hippocampus of Sprague Dawley rat brain, on subsequent exposure to naphthalene balls. The ultrastructural changes were observed for naphthalene low dose (200 mg), high dose (400 mg) after the treatment for 28 days, and post-delayed toxicity phase after 14 days in Sprague Dawley rats.
UNASSIGNED: In comparison with different groups of naphthalene exposure including control and satellite, axon degeneration, axonal demyelination and abnormal synapses was observed in high dose naphthalene administration group. In the post-delayed naphthalene toxicity group, degeneration of synaptic contacts was observed.
UNASSIGNED: This exploration of ultrastructural variations in the synapses of Hippocampus gives information that will be valued in naphthalene neurotoxicological research.
摘要：
■突触接触在中枢神经系统（CNS）功能中起重要作用。在萘神经毒性模型中没有研究中枢神经系统突触的超微结构特征。
■在目前的工作中，透射电子显微镜用于研究SpragueDawley大鼠大脑海马突触的超微结构特征，在随后接触萘球时。观察到萘低剂量（200mg）的超微结构变化，治疗28天后高剂量（400毫克），和SpragueDawley大鼠14天后的延迟毒性阶段。
■与包括对照和卫星在内的不同组的萘暴露相比，轴突变性,在高剂量萘组观察到轴突脱髓鞘和异常突触。在延迟后的萘毒性组中，观察到突触接触变性。
■对海马突触超微结构变化的探索提供了在萘神经毒理学研究中具有价值的信息。
■在目前的工作中，透射电子显微镜用于研究SpragueDawley大鼠大脑海马突触的超微结构特征，在随后接触萘球时。观察到萘低剂量（200mg）的超微结构变化，治疗28天后高剂量（400毫克），和SpragueDawley大鼠14天后的延迟毒性阶段。
■与包括对照和卫星在内的不同组的萘暴露相比，轴突变性,在高剂量萘组观察到轴突脱髓鞘和异常突触。在延迟后的萘毒性组中，观察到突触接触变性。
■对海马突触超微结构变化的探索提供了在萘神经毒理学研究中具有价值的信息。
