PDF(Pubmed)
Abstract：
UNASSIGNED: The Vitis vinifera, also known as grapevine, is one of the most widely grown fruit crops in the world and is renowned for producing wine and grapes. Other than their importance in gastronomy and ecology, certain sections of the V. vinifera plant have shown promising bioactive qualities. The numerous phytochemicals in this plant, including flavonoids, stilbenes, and phenolic acids, are what gives its antibacterial and antifungal properties though the antimicrobial properties of seed extract have to be studied, however in this present study we focus on screening and its biological compatibility of seed extracts of V. vinifera.
UNASSIGNED: The commercial power of seed (V. vinifera) obtained from local market near Poonamallee, Chennai, India. and the extraction of crude metabolites was done by direction extraction method, the antimicrobial activity was done by well diffusion method, and Minimum Inhibitory concentration was done by CLSI guideline. To check the biocompatibility of crude metabolites was done by hemolytic assay.
UNASSIGNED: Studies have demonstrated that grapevine extracts and their separated components have potent antibacterial and antifungal effects against a variety of pathogenic microorganisms, including bacterial strains that are resistant to antibiotics. The Minimum Inhibitory Concentration of the plant\'s extracts have demonstrated potential 128 µg/mL for S. aureus, and 256 µg/mL E. faecalis and C. albicans as the best inhibitory concentration. The biological compatibility of crude metabolites shows 3 % of lysis at 512 µg/mL.
UNASSIGNED: V. vinifera is a prospective source for the creation of novel antimicrobial drugs because of its antibacterial capabilities. To completely understand the chemicals\' mode of action and to create efficient treatments for microbial illnesses, more research is necessary.
UNASSIGNED: The commercial power of seed (V. vinifera) obtained from local market near Poonamallee, Chennai, India. and the extraction of crude metabolites was done by direction extraction method, the antimicrobial activity was done by well diffusion method, and Minimum Inhibitory concentration was done by CLSI guideline. To check the biocompatibility of crude metabolites was done by hemolytic assay.
UNASSIGNED: Studies have demonstrated that grapevine extracts and their separated components have potent antibacterial and antifungal effects against a variety of pathogenic microorganisms, including bacterial strains that are resistant to antibiotics. The Minimum Inhibitory Concentration of the plant\'s extracts have demonstrated potential 128 µg/mL for S. aureus, and 256 µg/mL E. faecalis and C. albicans as the best inhibitory concentration. The biological compatibility of crude metabolites shows 3 % of lysis at 512 µg/mL.
UNASSIGNED: V. vinifera is a prospective source for the creation of novel antimicrobial drugs because of its antibacterial capabilities. To completely understand the chemicals\' mode of action and to create efficient treatments for microbial illnesses, more research is necessary.
摘要：
■葡萄，也被称为葡萄藤，是世界上种植最广泛的水果作物之一，以生产葡萄酒和葡萄而闻名。除了它们在美食和生态学中的重要性，V.vinifera植物的某些部分显示出有希望的生物活性品质。这种植物中的众多植物化学物质，包括类黄酮,二苯乙烯,和酚酸，是什么给它的抗菌和抗真菌特性，虽然种子提取物的抗菌特性必须进行研究，然而，在本研究中，我们专注于筛选及其生物相容性的种子提取物。
■种子的商业力量（V.vinifera）从Poonamallee附近的当地市场获得，钦奈,印度。粗代谢物的提取采用方向提取法，抗菌活性是通过良好的扩散方法完成的，最低抑制浓度按CLSI指南进行。为了检查粗代谢物的生物相容性,通过溶血测定进行。
■研究表明，葡萄提取物及其分离的成分对多种病原微生物具有有效的抗菌和抗真菌作用，包括对抗生素有抗性的细菌菌株。植物提取物的最小抑制浓度已证明对金黄色葡萄球菌的潜在128µg/mL，和256µg/mL粪肠球菌和白色念珠菌为最佳抑制浓度。粗代谢物的生物相容性在512μg/mL时显示3%的裂解。
■V.由于其抗菌能力，vinifera是创造新型抗菌药物的潜在来源。为了完全了解化学物质的作用模式，并为微生物疾病创造有效的治疗方法，更多的研究是必要的。
■种子的商业力量（V.vinifera）从Poonamallee附近的当地市场获得，钦奈,印度。粗代谢物的提取采用方向提取法，抗菌活性是通过良好的扩散方法完成的，最低抑制浓度按CLSI指南进行。为了检查粗代谢物的生物相容性,通过溶血测定进行。
■研究表明，葡萄提取物及其分离的成分对多种病原微生物具有有效的抗菌和抗真菌作用，包括对抗生素有抗性的细菌菌株。植物提取物的最小抑制浓度已证明对金黄色葡萄球菌的潜在128µg/mL，和256µg/mL粪肠球菌和白色念珠菌为最佳抑制浓度。粗代谢物的生物相容性在512μg/mL时显示3%的裂解。
■V.由于其抗菌能力，vinifera是创造新型抗菌药物的潜在来源。为了完全了解化学物质的作用模式，并为微生物疾病创造有效的治疗方法，更多的研究是必要的。
