PDF(Pubmed)
Abstract：
UNASSIGNED: To determine the value of an algorithm for reducing stair-step artifacts for advanced coronary analyses in sequential mode coronary CT angiography (CCTA).
UNASSIGNED: Forty patients undergoing sequential mode photon-counting detector CCTA with at least one stair-step artifact were included. Twenty patients (14 males; mean age 57±17years) with 45 segments showing stair-step artifacts and without atherosclerosis were included for CTFFR analysis. Twenty patients (20 males; mean age 74±13years) with 22 segments showing stair-step artifacts crossing an atherosclerotic plaque were included for quantitative plaque analysis. Artifacts were graded, and CTFFR and quantitative coronary plaque analyses were performed in standard reconstructions and in those reconstructed with a software (entitled ZeeFree) for artifact reduction.
UNASSIGNED: Stair-step artifacts were significantly reduced in ZeeFree compared to standard reconstructions (p<0.05). In standard reconstructions, CTFFR was not feasible in 3/45 (7 %) segments but was feasible in all ZeeFree reconstructions. In 9/45 (20 %) segments without atherosclerosis, the ZeeFree algorithm led to a change of CTFFR values from pathologic in standard to physiologic values in ZeeFree reconstructions. In one segment (1/22, 5 %), quantitative plaque analysis was not feasible in standard but only in ZeeFree reconstruction. The mean overall plaque volume (111±60 mm3), the calcific (77±47 mm3), fibrotic (31±28 mm3), and lipidic (4±3 mm3) plaque components were higher in standard than in ZeeFree reconstructions (overall 75±50 mm3, p<0.001; calcific 51±42 mm3, p<0.001; fibrotic 22±19 mm3, p<0.05; lipidic 3±3 mm3, p=0.055).
UNASSIGNED: Despite the lack of reference standard modalities for CTFFR and coronary plaque analysis, initial evidence indicates that an algorithm for reducing stair-step artifacts in sequential mode CCTA increases the rate and quality of datasets amenable to advanced coronary artery analysis, hereby potentially improving patient management.
UNASSIGNED: Forty patients undergoing sequential mode photon-counting detector CCTA with at least one stair-step artifact were included. Twenty patients (14 males; mean age 57±17years) with 45 segments showing stair-step artifacts and without atherosclerosis were included for CTFFR analysis. Twenty patients (20 males; mean age 74±13years) with 22 segments showing stair-step artifacts crossing an atherosclerotic plaque were included for quantitative plaque analysis. Artifacts were graded, and CTFFR and quantitative coronary plaque analyses were performed in standard reconstructions and in those reconstructed with a software (entitled ZeeFree) for artifact reduction.
UNASSIGNED: Stair-step artifacts were significantly reduced in ZeeFree compared to standard reconstructions (p<0.05). In standard reconstructions, CTFFR was not feasible in 3/45 (7 %) segments but was feasible in all ZeeFree reconstructions. In 9/45 (20 %) segments without atherosclerosis, the ZeeFree algorithm led to a change of CTFFR values from pathologic in standard to physiologic values in ZeeFree reconstructions. In one segment (1/22, 5 %), quantitative plaque analysis was not feasible in standard but only in ZeeFree reconstruction. The mean overall plaque volume (111±60 mm3), the calcific (77±47 mm3), fibrotic (31±28 mm3), and lipidic (4±3 mm3) plaque components were higher in standard than in ZeeFree reconstructions (overall 75±50 mm3, p<0.001; calcific 51±42 mm3, p<0.001; fibrotic 22±19 mm3, p<0.05; lipidic 3±3 mm3, p=0.055).
UNASSIGNED: Despite the lack of reference standard modalities for CTFFR and coronary plaque analysis, initial evidence indicates that an algorithm for reducing stair-step artifacts in sequential mode CCTA increases the rate and quality of datasets amenable to advanced coronary artery analysis, hereby potentially improving patient management.
摘要：
■为了确定在顺序模式冠状动脉CT血管造影（CCTA）中减少高级冠状动脉分析的阶梯伪影的算法的价值。
■40例患者接受序贯模式光子计数探测器CCTA，至少有一个阶梯伪影。CTFFR分析包括20例患者（14例男性；平均年龄57±17岁），其中45个节段显示阶梯状伪影且无动脉粥样硬化。纳入20例患者（20例男性；平均年龄74±13岁），其中22个节段显示出穿过动脉粥样硬化斑块的阶梯伪影，用于定量斑块分析。文物被分级，在标准重建和使用软件(名为ZeeFree)重建的患者中进行CTFFR和定量冠状动脉斑块分析,以减少伪影.
■与标准重建相比，ZeeFree中的阶梯伪影明显减少（p<0.05）。在标准重建中，CTFFR在3/45（7％）段中不可行，但在所有ZeeFree重建中均可行。在无动脉粥样硬化的9/45（20％）段中，在ZeeFree重建中,ZeeFree算法导致CTFFR值从病理标准值变为生理值.在一个部分（1/22，5%），定量斑块分析在标准中不可行，但仅在ZeeFree重建中可行。平均总斑块体积（111±60mm3），钙化（77±47mm3），纤维化（31±28mm3），和脂质（4±3mm3）斑块成分标准高于ZeeFree重建（总体75±50mm3，p<0.001；钙化51±42mm3，p<0.001；纤维化22±19mm3，p<0.05；脂质3±3mm3，p=0.055）。
■尽管缺乏CTFFR和冠状动脉斑块分析的参考标准模式，初步证据表明，在顺序模式CCTA中减少阶梯伪影的算法增加了适合于高级冠状动脉分析的数据集的速率和质量，因此有可能改善患者管理。
■40例患者接受序贯模式光子计数探测器CCTA，至少有一个阶梯伪影。CTFFR分析包括20例患者（14例男性；平均年龄57±17岁），其中45个节段显示阶梯状伪影且无动脉粥样硬化。纳入20例患者（20例男性；平均年龄74±13岁），其中22个节段显示出穿过动脉粥样硬化斑块的阶梯伪影，用于定量斑块分析。文物被分级，在标准重建和使用软件(名为ZeeFree)重建的患者中进行CTFFR和定量冠状动脉斑块分析,以减少伪影.
■与标准重建相比，ZeeFree中的阶梯伪影明显减少（p<0.05）。在标准重建中，CTFFR在3/45（7％）段中不可行，但在所有ZeeFree重建中均可行。在无动脉粥样硬化的9/45（20％）段中，在ZeeFree重建中,ZeeFree算法导致CTFFR值从病理标准值变为生理值.在一个部分（1/22，5%），定量斑块分析在标准中不可行，但仅在ZeeFree重建中可行。平均总斑块体积（111±60mm3），钙化（77±47mm3），纤维化（31±28mm3），和脂质（4±3mm3）斑块成分标准高于ZeeFree重建（总体75±50mm3，p<0.001；钙化51±42mm3，p<0.001；纤维化22±19mm3，p<0.05；脂质3±3mm3，p=0.055）。
■尽管缺乏CTFFR和冠状动脉斑块分析的参考标准模式，初步证据表明，在顺序模式CCTA中减少阶梯伪影的算法增加了适合于高级冠状动脉分析的数据集的速率和质量，因此有可能改善患者管理。
