PDF(Pubmed)
Abstract：
UNASSIGNED: Hypertensive disorders in pregnancy account for 15%-20% maternal and 20%-25% perinatal mortality. There is interest in predicting preeclampsia (PE) early in pregnancy to reduce PE and its subsequent complications. There is no cheap and easily available, reliable predictor for PE. Some studies have shown that the lateral location of placenta is associated with adverse pregnancy outcomes due to PE. The lateral placenta is yet to be proven as a strong predictor of PE to initiate preventive measures. Placental localization can be easily done on routine ultrasonography during pregnancy. In the light of these observations, a prospective study was done to study any association between PE and placental location by ultrasound in third trimester. Research Question: Is there any association between placental location on ultrasound and preeclampsia in third trimester? The objective is to study association between location of placenta and preeclampsia and compare placental location in normotensive pregnancies with that in PE in third trimester.
UNASSIGNED: A prospective comparative, case-control, observational study was conducted in the Department of Obstetrics and Gynecology at North DMC Medical College and Hindu Rao Hospital, Delhi, India, from August 2019 to April 2020. The study population included 200 pregnant women with singleton pregnancy in third trimester, without any medical disorders such as diabetes mellitus, hypertension, renal disease, cardiac disease, and coagulation disorder or smoking. One hundred women had preeclampsia and 100 were normotensive controls. Ultrasound was done after filling F form as per the Government of India guidelines to rule out sex determination, and placenta was localized by ultrasound. Placenta was classified as central when it was equally distributed between the right and left sides of the uterus irrespective of anterior, posterior, or fundal position and lateral when 75% or more of the placental mass was on one side of the midline. Placental location was compared in hypertensive and normotensive pregnancies.
UNASSIGNED: Out of the total 200 women, 152 (76%) had central and 48 (24%) had lateral placenta. Ninety-two percent of controls and 60% of cases had central placenta. Forty percent of cases and only 8% normotensive women had lateral placenta. Lateral placenta was five times more frequent in presence of PE as compared to normotensive controls. Out of 152 women with central placenta, 92 (60.5%) women were normotensive but with lateral placenta, only 8 (16.7%) had normal blood pressure. PE was present in 83% of women with lateral placenta and in only 39.47% with central placenta. This difference was statistically significant as P < 0.0001 as per Chi-square test. This reflects a significant association between lateral position of placenta and occurrence of PE. As per odds ratio (0.1304) patients without lateral placenta had 90% protection against preeclampsia.
UNASSIGNED: Central placenta is more common than lateral placenta. Lateral placenta is seen five times more frequently among hypertensive women and this difference is statistically significant. The absence of lateral placenta provides 90% protection against PE but the severity of PE was not affected by placental location..
UNASSIGNED: A prospective comparative, case-control, observational study was conducted in the Department of Obstetrics and Gynecology at North DMC Medical College and Hindu Rao Hospital, Delhi, India, from August 2019 to April 2020. The study population included 200 pregnant women with singleton pregnancy in third trimester, without any medical disorders such as diabetes mellitus, hypertension, renal disease, cardiac disease, and coagulation disorder or smoking. One hundred women had preeclampsia and 100 were normotensive controls. Ultrasound was done after filling F form as per the Government of India guidelines to rule out sex determination, and placenta was localized by ultrasound. Placenta was classified as central when it was equally distributed between the right and left sides of the uterus irrespective of anterior, posterior, or fundal position and lateral when 75% or more of the placental mass was on one side of the midline. Placental location was compared in hypertensive and normotensive pregnancies.
UNASSIGNED: Out of the total 200 women, 152 (76%) had central and 48 (24%) had lateral placenta. Ninety-two percent of controls and 60% of cases had central placenta. Forty percent of cases and only 8% normotensive women had lateral placenta. Lateral placenta was five times more frequent in presence of PE as compared to normotensive controls. Out of 152 women with central placenta, 92 (60.5%) women were normotensive but with lateral placenta, only 8 (16.7%) had normal blood pressure. PE was present in 83% of women with lateral placenta and in only 39.47% with central placenta. This difference was statistically significant as P < 0.0001 as per Chi-square test. This reflects a significant association between lateral position of placenta and occurrence of PE. As per odds ratio (0.1304) patients without lateral placenta had 90% protection against preeclampsia.
UNASSIGNED: Central placenta is more common than lateral placenta. Lateral placenta is seen five times more frequently among hypertensive women and this difference is statistically significant. The absence of lateral placenta provides 90% protection against PE but the severity of PE was not affected by placental location..
摘要：
■妊娠期高血压疾病占15%-20%的孕产妇死亡率和20%-25%的围产期死亡率。在妊娠早期预测先兆子痫（PE）以减少PE及其随后的并发症是有兴趣的。没有便宜和容易获得的，PE的可靠预测指标。一些研究表明，胎盘的外侧位置与PE引起的不良妊娠结局有关。外侧胎盘尚未被证明是PE的有力预测因子，以启动预防措施。在怀孕期间的常规超声检查中可以很容易地进行胎盘定位。根据这些观察,我们进行了一项前瞻性研究,目的是通过妊娠晚期超声检查来研究PE与胎盘位置之间的关联.研究问题：超声检查胎盘位置与妊娠晚期子痫前期之间是否有关联？目的是研究胎盘位置与子痫前期之间的关联，并比较正常妊娠与妊娠晚期PE的胎盘位置。
■前瞻性比较，病例控制，观察性研究是在北DMC医学院和印度教饶医院的妇产科进行的，德里,印度,从2019年8月到2020年4月。研究人群包括200名妊娠晚期单胎妊娠的孕妇，没有任何疾病，如糖尿病，高血压,肾脏疾病,心脏病,和凝血障碍或吸烟。100名妇女患有先兆子痫，100名是血压正常的对照。根据印度政府指南填写F表格后进行超声检查，以排除性别确定，胎盘通过超声定位。当胎盘在子宫的右侧和左侧之间均匀分布时，胎盘被归类为中央，而与子宫的前部无关。后部,或当75％或更多的胎盘质量在中线的一侧时，底位和外侧。在高血压和正常血压妊娠中比较了胎盘位置。
■在总共200名女性中，152（76％）有中央胎盘，48（24％）有外侧胎盘。92%的对照组和60%的病例有中央胎盘。40%的病例和只有8%血压正常的女性有外侧胎盘。与血压正常的对照组相比，在存在PE的情况下，外侧胎盘的频率是后者的五倍。152名中央胎盘女性中,92名(60.5%)女性血压正常，但胎盘外侧，只有8人(16.7%)血压正常。83％的外侧胎盘女性存在PE，仅39.47％的中央胎盘女性存在PE。这种差异是统计学上显著的,如根据卡方检验P<0.0001。这反映了胎盘侧位与PE发生之间的显著关联。根据比值比（0.1304），没有外侧胎盘的患者对先兆子痫的保护率为90％。
■中央胎盘比外侧胎盘更常见。在高血压女性中，侧面胎盘的发生率是女性的五倍，这种差异具有统计学意义。外侧胎盘的缺失提供了对PE的90%保护,但是PE的严重程度不受胎盘位置的影响。.
■前瞻性比较，病例控制，观察性研究是在北DMC医学院和印度教饶医院的妇产科进行的，德里,印度,从2019年8月到2020年4月。研究人群包括200名妊娠晚期单胎妊娠的孕妇，没有任何疾病，如糖尿病，高血压,肾脏疾病,心脏病,和凝血障碍或吸烟。100名妇女患有先兆子痫，100名是血压正常的对照。根据印度政府指南填写F表格后进行超声检查，以排除性别确定，胎盘通过超声定位。当胎盘在子宫的右侧和左侧之间均匀分布时，胎盘被归类为中央，而与子宫的前部无关。后部,或当75％或更多的胎盘质量在中线的一侧时，底位和外侧。在高血压和正常血压妊娠中比较了胎盘位置。
■在总共200名女性中，152（76％）有中央胎盘，48（24％）有外侧胎盘。92%的对照组和60%的病例有中央胎盘。40%的病例和只有8%血压正常的女性有外侧胎盘。与血压正常的对照组相比，在存在PE的情况下，外侧胎盘的频率是后者的五倍。152名中央胎盘女性中,92名(60.5%)女性血压正常，但胎盘外侧，只有8人(16.7%)血压正常。83％的外侧胎盘女性存在PE，仅39.47％的中央胎盘女性存在PE。这种差异是统计学上显著的,如根据卡方检验P<0.0001。这反映了胎盘侧位与PE发生之间的显著关联。根据比值比（0.1304），没有外侧胎盘的患者对先兆子痫的保护率为90％。
■中央胎盘比外侧胎盘更常见。在高血压女性中，侧面胎盘的发生率是女性的五倍，这种差异具有统计学意义。外侧胎盘的缺失提供了对PE的90%保护,但是PE的严重程度不受胎盘位置的影响。.
