PDF(Pubmed)
Abstract：
Hypercholesterolemia is a metabolic disease characterized by elevated cholesterol level in the blood, which is a risk factor for many diseases. Probiotic intervention may be one of the ways to improve hypercholesterolemia. In this study, three strains with better cholesterol removal ability were selected from 60 strains of lactic acid bacteria, and were orally administered to apolipoprotein E-deficient mice on a high-cholesterol diet. Among the three strains, only Limosilactobacillus fermentum TY-S11, which was isolated from the intestine of a longevity person, significantly improved serum and liver lipid levels in hypercholesterolemic mice. Further study found that L. fermentum TY-S11 promoted the excretion of cholesterol in the feces and inhibited the absorption of cholesterol in the small intestine. As for gut microbiota, the results showed that L. fermentum TY-S11 not only prevented the reduction of diversity caused by high-cholesterol diet, but also increased the contents of short-chain fatty acids in feces. These results confirmed the ameliorative effect of L. fermentum TY-S11 on hypercholesterolemia.
摘要：
高胆固醇血症是一种代谢疾病，其特征是血液中胆固醇水平升高，这是许多疾病的危险因素。益生菌干预可能是改善高胆固醇血症的方法之一。在这项研究中,从60株乳酸菌中筛选出3株胆固醇去除能力较好的菌株,并口服给予高胆固醇饮食的载脂蛋白E缺陷小鼠。在这三个菌株中，只有从长寿者的肠道中分离出的发酵LimosilactobacillusTY-S11，显著改善高胆固醇血症小鼠的血清和肝脏脂质水平。进一步研究发现，发酵乳杆菌TY-S11促进粪便中胆固醇的排泄，抑制小肠中胆固醇的吸收。至于肠道菌群，结果表明，发酵乳杆菌TY-S11不仅可以防止高胆固醇饮食引起的多样性降低，而且还增加了粪便中短链脂肪酸的含量。这些结果证实了发酵乳杆菌TY-S11对高胆固醇血症的改善作用。
