PDF(Pubmed)
Abstract：
The T cell is an immune cell subset highly effective in eliminating cancer cells. Cancer immunotherapy empowers T cells and occupies a solid position in cancer treatment. The response rate, however, remains relatively low (<30%). The efficacy of immunotherapy is highly dependent on T cell infiltration into the tumor microenvironment (TME) and the ability of these infiltrated T cells to sustain their function within the TME. A better understanding of the inhibitory impact of the TME on T cells is crucial to improve cancer immunotherapy. Tumor cells are well described for their switch into aerobic glycolysis (Warburg effect), resulting in high glucose consumption and a metabolically distinct TME. Conversely, glycosylation, a predominant posttranslational modification of proteins, also relies on glucose molecules. Proper glycosylation of T cell receptors influences the immunological synapse between T cells and tumor cells, thereby affecting T cell effector functions including their cytolytic and cytostatic activities. This review delves into the complex interplay between tumor glucose metabolism and the glycocalyx of T cells, shedding light on how the TME can induce alterations in the T cell glycocalyx, which can subsequently influence the T cell\'s ability to target and eliminate tumor cells.
摘要：
T细胞是在消除癌细胞方面非常有效的免疫细胞亚群。癌症免疫疗法赋予T细胞功能，并在癌症治疗中占有重要地位。响应率，然而,相对较低（<30%）。免疫疗法的功效高度依赖于T细胞浸润到肿瘤微环境(TME)中以及这些浸润的T细胞维持其在TME内的功能的能力。更好地了解TME对T细胞的抑制作用对于改善癌症免疫疗法至关重要。肿瘤细胞被很好地描述为它们转变为有氧糖酵解（Warburg效应），导致高葡萄糖消耗和代谢上不同的TME。相反，糖基化，蛋白质的主要翻译后修饰，也依赖于葡萄糖分子。T细胞受体的正确糖基化影响T细胞和肿瘤细胞之间的免疫突触，从而影响T细胞效应子功能,包括其细胞溶解和细胞抑制活性。这篇综述探讨了肿瘤葡萄糖代谢和T细胞糖萼之间复杂的相互作用。阐明TME如何诱导T细胞糖萼的改变，这随后会影响T细胞靶向和消除肿瘤细胞的能力。
