METHODS: It was a hospital-based case-control study in which 120 male patients with MS and 120 age-matched controls were enroled. Demographic profiles, anthropometry, past illnesses, and medical history of patients were obtained. MS was diagnosed according to the International Diabetes Federation (IDF) criteria and was measured using the flow-mediated dilation (FMD) method with the help of ultrasound used to assess endothelial dysfunction. Diagnosis of ED was based on the International Index of Erectile Function (IIEF) scale.
RESULTS: The study participants had a mean age of 40.91 ± 11.41 years. The majority of cases (57.5%) had ≤6 months of history of MS. The prevalence of ED was 31.7% in cases compared to 5% in controls, thus showing a significant difference between cases and controls. Mean IIEF scores were significantly lower in cases (18.82 ± 5.59) compared to those in controls (23.00 ± 2.57). A moderate positive and significant correlation was observed between FMD and IIEF scores. With an increasing number of MS components, there was a significant increase in the prevalence of ED. Those with ED had significantly lower mean FMD values (5.1 ± 1.1%) compared to those not having ED (10.9 ± 3.3%).
CONCLUSIONS: The findings of the present study showed that there is a significant association between ED and MS. We observed that the increase in components of MS increased the prevalence of ED in MS. Endothelial dysfunction measured by FMD was correlated with ED.
方法:这是一项基于医院的病例对照研究,纳入了120例男性MS患者和120例年龄匹配的对照。人口概况,人体测量学,过去的疾病,并获得患者病史。根据国际糖尿病联合会(IDF)标准诊断MS,并在超声评估内皮功能障碍的帮助下使用流量介导的扩张(FMD)方法进行测量。ED的诊断基于国际勃起功能指数(IIEF)量表。
结果:研究参与者的平均年龄为40.91±11.41岁。大多数病例(57.5%)有≤6个月的MS病史。病例中ED的患病率为31.7%,对照组为5%,因此显示病例和对照之间的显著差异。病例的平均IIEF评分(18.82±5.59)明显低于对照组(23.00±2.57)。在FMD和IIEF评分之间观察到中度正相关和显著相关。随着MS组件数量的增加,ED的患病率显着增加。与未患有ED的患者(10.9±3.3%)相比,患有ED的患者的平均FMD值(5.1±1.1%)显着降低。
结论:本研究的结果表明ED与MS之间存在显着关联。我们观察到MS成分的增加增加了MS中ED的患病率。FMD测量的内皮功能障碍与ED相关。