Abstract：
A 72-year-old male was referred with a 2-week history of diplopia. Following magnetic resonance imaging, an area of abnormal signal intensity was observed along the lateral ventricle, without any unusual findings at other sites. Cerebrospinal fluid cytology revealed abnormal lymphocytes with atypia, which were positive for CD20 and light-chain restriction, as detected by surface marker analysis, leading to a diagnosis of primary meningeal B-cell lymphoma. The patient underwent chemoradiotherapy and achieved a remission. While meningeal lymphoma is a rare occurrence, pathological tissue biopsy is considered the gold-standard diagnostic method. However, obtaining a biopsy sample from the tumor site can be challenging. In this case report, cytology and flow cytometry played a vital role in the diagnosis of meningeal lymphoma.
摘要：
一名72岁的男性被转诊，有2周的复视史。磁共振成像之后,沿侧脑室观察到异常信号强度区域，在其他地点没有任何不寻常的发现。脑脊液细胞学检查显示异常淋巴细胞异型，CD20和轻链限制呈阳性，通过表面标记分析检测到，导致原发性脑膜B细胞淋巴瘤的诊断。患者接受了放化疗并获得缓解。虽然脑膜淋巴瘤是罕见的，病理组织活检被认为是金标准诊断方法。然而,从肿瘤部位获得活检样本可能是具有挑战性的。在这个案例报告中,细胞学和流式细胞术在脑膜淋巴瘤的诊断中起着至关重要的作用。
