Abstract：
Despite increasing prevalence of hypertension in youth and high adult cardiovascular mortality rates, the long-term consequences of youth-onset hypertension remain unknown. This is due to limitations of prior research such as small sample sizes, reliance on manual record review, and limited analytic methods that did not address major biases. The Study of the Epidemiology of Pediatric Hypertension (SUPERHERO) is a multisite retrospective Registry of youth evaluated by subspecialists for hypertension disorders. Sites obtain harmonized electronic health record data using standardized biomedical informatics scripts validated with randomized manual record review. Inclusion criteria are index visit for International Classification of Diseases Diagnostic Codes, 10th Revision (ICD-10 code)-defined hypertension disorder ≥January 1, 2015 and age <19 years. We exclude patients with ICD-10 code-defined pregnancy, kidney failure on dialysis, or kidney transplantation. Data include demographics, anthropomorphics, U.S. Census Bureau tract, histories, blood pressure, ICD-10 codes, medications, laboratory and imaging results, and ambulatory blood pressure. SUPERHERO leverages expertise in epidemiology, statistics, clinical care, and biomedical informatics to create the largest and most diverse registry of youth with newly diagnosed hypertension disorders. SUPERHERO\'s goals are to (i) reduce CVD burden across the life course and (ii) establish gold-standard biomedical informatics methods for youth with hypertension disorders.
摘要：
尽管年轻人高血压患病率增加，成年人心血管死亡率高，青少年期高血压的长期后果尚不清楚.这是由于先前研究的局限性，如样本量小，依赖人工记录审查，和有限的分析方法，没有解决主要偏见。儿童高血压流行病学研究（SUPERHERO）是一项由高血压专科医生评估的青年多中心回顾性注册。站点使用经随机手动记录审查验证的标准化生物医学信息学脚本获得统一的电子健康记录数据。纳入标准是国际疾病分类诊断代码的索引访问，第10次修订（ICD-10代码）定义的高血压障碍≥2015年1月1日且年龄<19岁。我们排除ICD-10代码定义妊娠的患者，透析时肾衰竭，或者肾移植.数据包括人口统计，拟人化,美国人口普查局，历史,血压,ICD-10代码,药物,实验室和成像结果，和动态血压。SUPERHERO利用流行病学方面的专业知识，统计数据，临床护理,和生物医学信息学，以创建新诊断的高血压疾病青年的最大和最多样化的注册表。SUPERHERO的目标是（i）减少整个生命过程中的CVD负担，以及（ii）为患有高血压疾病的年轻人建立黄金标准的生物医学信息学方法。
