关键词: Asian dust case-crossover design environmental pollutant pneumonia real-world database

来  源:   DOI:10.1177/10105395241260978

Abstract:
Epidemiological studies have reported that Asian dust (AD), a type of desert dust, has harmful effects on human health. This study aimed to examine the association between AD exposure and hospitalization due to pneumonia. Data on patients in Western Japan admitted for pneumonia were included from a real-world database derived from electronic medical records. We used the meteorological observatory data of the most populous city in each prefecture, in which AD event was defined as a loss of visibility from a distance ≤10 km. A case-crossover design and conditional logistic regression model were used. Overall, 12 938 patients were included, and AD exposure events were observed for 557 days. Exposure to an AD event five days prior to hospitalization was significantly associated with hospitalization for pneumonia after adjusting for weather variables (odds ratio = 1.17; 95% confidence interval = [1.01, 1.36]). These findings suggest that AD exposure is associated with an increased rate of admission for pneumonia in Western Japan.
摘要:
流行病学研究报告说,亚洲尘埃(AD),一种沙漠尘埃,对人体健康有有害影响。这项研究旨在检查AD暴露与肺炎住院之间的关系。日本西部因肺炎入院的患者数据来自电子病历的真实数据库。我们使用了每个州人口最多的城市的气象观测数据,其中AD事件定义为距离≤10km的能见度丧失。使用案例交叉设计和条件逻辑回归模型。总的来说,纳入12938例患者,和AD暴露事件观察557天。在调整天气变量后,住院前五天暴露于AD事件与肺炎住院显著相关(比值比=1.17;95%置信区间=[1.01,1.36])。这些发现表明,在日本西部,AD暴露与肺炎入院率增加有关。
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