Abstract：
Tumor necrosis factor (TNF) is one of many cytokines - protein molecules responsible for communication between the cells of immune system. TNF was discovered and given its grand name because of its striking antitumor effects in experimental systems, but its main physiological functions in the context of whole organism turned out to be completely unrelated to protection against tumors. This short review discusses \"man-made\" mouse models generated by early genome-editing technologies, which enabled us to establish true functions of TNF in health and certain diseases as well as to unravel potential strategies for improving therapy of TNF-dependent diseases.
摘要：
肿瘤坏死因子（TNF）是许多细胞因子之一-负责免疫系统细胞之间通讯的蛋白质分子。TNF因其在实验系统中具有惊人的抗肿瘤作用而被发现并被命名。但是它在整个生物体中的主要生理功能与肿瘤的保护完全无关。这篇简短的评论讨论了早期基因组编辑技术产生的“人造”小鼠模型，这使我们能够确定TNF在健康和某些疾病中的真正功能，并揭示改善TNF依赖性疾病治疗的潜在策略。
