Abstract：
A large proportion of cancer patients present with unresectable bulky disease at baseline or following treatment failure. The data available in the literature suggest that the vast majority of these patients do not benefit from available standard therapies. Therefore the clinical outcomes are poor; patients are desperate and usually relegated to palliative or best supportive care as the only options. Large tumor masses are usually hypoxic, resistant to radiation and systemic therapy, with extensive regional infiltration of the surrounding critical organs, the presence of which makes it impossible to deliver a radical dose of radiation. Promising data in terms of improved therapeutic ratio where such complex tumors are concerned can be seen with the use of new emerging unconventional radiotherapy techniques known as spatially fractionated radiotherapies (SFRT). One of them is PATHY, or PArtial Tumor irradiation targeting HYpoxic segment, which is characterized by a very short treatment course offering a large spectrum of therapeutic benefits in terms of the symptom relief, quality of life, local tumor control, neoadjuvant and immunomodulatory effects.
摘要：
大部分癌症患者在基线或治疗失败后出现不可切除的大体积疾病。文献中可获得的数据表明，这些患者中的绝大多数无法从可用的标准疗法中受益。因此，临床结果很差；患者绝望，通常只能选择姑息治疗或最佳支持治疗。大的肿瘤肿块通常是缺氧的，耐辐射和全身治疗，随着周围关键器官的广泛区域渗透，它的存在使得不可能提供激进剂量的辐射。通过使用称为空间分割放射疗法（SFRT）的新兴非常规放射疗法技术，可以看到有关此类复杂肿瘤的改善治疗比率方面的有希望的数据。其中之一是Pathy,或靶向缺氧节段的原发性肿瘤照射，其特点是治疗过程非常短，在症状缓解方面提供了大量的治疗益处，生活质量,局部肿瘤控制,新辅助和免疫调节作用。
