Abstract：
White feces syndrome (WFS) is a multifactorial disease that affects global shrimp production. The diagnostic approach to identify WFS involves traditional and molecular scientific methods by examining histopathology, bioassays, PCR (polymerase chain reaction), and calorimetric estimation. The pathogenesis of WFS is closely associated with Vibrio spp., intestinal microbiota (IM) dysbiosis, and Enterocytozoon hepatopenaei (EHP). It also has caused over 10-15 % loss in the aquaculture industry and is also known to cause retardation, lethargy and slowly leading to high mortality in shrimp farms. Therefore, it is necessary to understand the molecular mechanisms processed under the association of IM dysbiosis, Vibrio spp., and EHP to analyze the impact of disease on the innate immune system of shrimp. However, only very few reviews have described the molecular pathways involved in WFS. Hence, this review aims to elucidate an in-depth analysis of molecular pathways involved in the innate immune system of shrimp and their response to pathogens. The analysis and understanding of the impact of shrimp\'s innate immune system on WFS would help in developing treatments to prevent the spread of disease, thereby improving the economic condition of shrimp farms worldwide.
摘要：
白粪便综合征（WFS）是一种多因素疾病，会影响全球对虾养殖场的生产。识别WFS的诊断方法涉及通过检查组织病理学的传统和分子科学方法，生物测定，PCR（聚合酶链反应），和量热估计。WFS的发病机制与弧菌属密切相关。,肠道微生物群（IM）菌群失调，和肠孢子虫肝减少症（EHP）。它还在水产养殖业中造成了超过10-15％的损失，并且还已知会导致发育迟缓，嗜睡和缓慢导致对虾养殖场的高死亡率。因此,有必要了解在IM菌群失调的关联下处理的分子机制，弧菌属。,和EHP分析疾病对虾先天免疫系统的影响。然而,只有很少的综述描述了WFS涉及的分子途径。因此，这篇综述旨在阐明对虾先天免疫系统的分子通路及其对病原体的反应。分析和了解对虾的先天免疫系统对WFS的影响将有助于开发治疗方法，以防止疾病的传播，从而改善了全球对虾养殖场的经济状况。
