Abstract：
Understanding the intricate interplay between sensory nerves and bone tissue cells is of paramount significance in the field of bone biology and clinical medicine. The regulatory role of sensory nerves in bone homeostasis offers a novel perspective for the development of targeted therapeutic interventions for a spectrum of bone-related diseases, including osteoarthritis, osteoporosis, and intervertebral disc degeneration. By elucidating the mechanisms through which sensory nerves and their neuropeptides influence the differentiation and function of bone tissue cells, this review aims to shed light on emerging therapeutic targets that harness the neuro-skeletal axis for the treatment and management of debilitating bone disorders. Moreover, a comprehensive understanding of sensory nerve-mediated bone regulation may pave the way for the development of innovative strategies to promote bone health and mitigate the burden of skeletal pathologies in clinical practice.
摘要：
了解感觉神经和骨组织细胞之间的复杂相互作用在骨生物学和临床医学领域具有至关重要的意义。感觉神经在骨稳态中的调节作用为一系列骨相关疾病的靶向治疗干预的发展提供了新的视角。包括骨关节炎,骨质疏松,椎间盘退变.通过阐明感觉神经及其神经肽影响骨组织细胞分化和功能的机制，这篇综述旨在阐明利用神经-骨骼轴来治疗和管理衰弱性骨骼疾病的新兴治疗靶点。此外，对感觉神经介导的骨调节的全面了解可能为开发促进骨骼健康和减轻临床实践中骨骼病变负担的创新策略铺平道路.
