Abstract：
OBJECTIVE: This study aimed to investigate the factors associated with perceived cognitive function among breast cancer patients treated with chemotherapy in China.
METHODS: The study was a multicenter cross-sectional design. Data were collected from 10 public hospitals in China between April 2022 and February 2023. A total of 741 participants completed questionnaires assessing sociodemographic and medical characteristics, perceived cognitive function, sleep quality, fatigue, anxiety, and depression. Hierarchical multiple regression analysis was used to assess the determinants of cognitive function.
RESULTS: The hierarchical multiple regression model accounted for 31.5% of variation in perceived cognitive function (sociodemographic 4.5%; medical 6.6%; exercise frequency 6.6%; sleep quality 2.1%; fatigue 2.8%; anxiety combined with depression 9.0%). Education level, chemotherapy type, number of chemotherapy cycles, and cyclophosphamide drug use were significant predisposing factors of perceived cognitive function (p < 0.001). Exercising ≥3 times/week (p < 0.001) was a significant factor positively influencing perceived cognitive function, meanwhile, anxiety (p < 0.001) and depression (p < 0 0.001) were negative factors.
CONCLUSIONS: Our findings suggest that patients with low education levels, postoperative chemotherapy, cyclophosphamide treatment, and a greater number of chemotherapy cycles need more assessment. Sedentary patients, those who have never exercised, and those with anxiety or depression all showed greater cognitive decline. By identifying susceptible populations, encouraging regular exercise, and addressing anxiety and depression, healthcare professionals can contribute significantly to prevent patients\' cognitive decline throughout chemotherapy.
METHODS: The study was a multicenter cross-sectional design. Data were collected from 10 public hospitals in China between April 2022 and February 2023. A total of 741 participants completed questionnaires assessing sociodemographic and medical characteristics, perceived cognitive function, sleep quality, fatigue, anxiety, and depression. Hierarchical multiple regression analysis was used to assess the determinants of cognitive function.
RESULTS: The hierarchical multiple regression model accounted for 31.5% of variation in perceived cognitive function (sociodemographic 4.5%; medical 6.6%; exercise frequency 6.6%; sleep quality 2.1%; fatigue 2.8%; anxiety combined with depression 9.0%). Education level, chemotherapy type, number of chemotherapy cycles, and cyclophosphamide drug use were significant predisposing factors of perceived cognitive function (p < 0.001). Exercising ≥3 times/week (p < 0.001) was a significant factor positively influencing perceived cognitive function, meanwhile, anxiety (p < 0.001) and depression (p < 0 0.001) were negative factors.
CONCLUSIONS: Our findings suggest that patients with low education levels, postoperative chemotherapy, cyclophosphamide treatment, and a greater number of chemotherapy cycles need more assessment. Sedentary patients, those who have never exercised, and those with anxiety or depression all showed greater cognitive decline. By identifying susceptible populations, encouraging regular exercise, and addressing anxiety and depression, healthcare professionals can contribute significantly to prevent patients\' cognitive decline throughout chemotherapy.
摘要：
目的：本研究旨在探讨中国乳腺癌化疗患者认知功能的相关因素。
方法：本研究采用多中心横断面设计。数据来自2022年4月至2023年2月期间中国10家公立医院。共有741名参与者完成了评估社会人口统计学和医学特征的问卷，感知认知功能，睡眠质量,疲劳,焦虑,和抑郁症。分层多元回归分析用于评估认知功能的决定因素。
结果：分层多元回归模型占感知认知功能变异的31.5％（社会人口学4.5％；医疗6.6％；运动频率6.6％；睡眠质量2.1％；疲劳2.8％；焦虑合并抑郁9.0％）。教育水平,化疗类型,化疗周期数，和环磷酰胺药物使用是感知认知功能的显著诱发因素(p<0.001)。运动≥3次/周(p<0.001)是影响感知认知功能的显著因素,同时,焦虑(p<0.001)和抑郁(p<0.001)是负面因素。
结论：我们的研究结果表明，受教育程度低的患者，术后化疗,环磷酰胺治疗，更多的化疗周期需要更多的评估。久坐的患者，那些从未锻炼过的人，那些焦虑或抑郁的人都表现出更大的认知能力下降。通过识别易感人群，鼓励经常锻炼，解决焦虑和抑郁，医疗保健专业人员可以显著有助于防止患者在整个化疗过程中的认知能力下降。
方法：本研究采用多中心横断面设计。数据来自2022年4月至2023年2月期间中国10家公立医院。共有741名参与者完成了评估社会人口统计学和医学特征的问卷，感知认知功能，睡眠质量,疲劳,焦虑,和抑郁症。分层多元回归分析用于评估认知功能的决定因素。
结果：分层多元回归模型占感知认知功能变异的31.5％（社会人口学4.5％；医疗6.6％；运动频率6.6％；睡眠质量2.1％；疲劳2.8％；焦虑合并抑郁9.0％）。教育水平,化疗类型,化疗周期数，和环磷酰胺药物使用是感知认知功能的显著诱发因素(p<0.001)。运动≥3次/周(p<0.001)是影响感知认知功能的显著因素,同时,焦虑(p<0.001)和抑郁(p<0.001)是负面因素。
结论：我们的研究结果表明，受教育程度低的患者，术后化疗,环磷酰胺治疗，更多的化疗周期需要更多的评估。久坐的患者，那些从未锻炼过的人，那些焦虑或抑郁的人都表现出更大的认知能力下降。通过识别易感人群，鼓励经常锻炼，解决焦虑和抑郁，医疗保健专业人员可以显著有助于防止患者在整个化疗过程中的认知能力下降。
