Abstract：
BACKGROUND: CPEB1 is an alternative polyadenylation binding protein that promotes or suppresses the expression of related mRNAs and proteins by binding to a highly conserved Cytoplasmic Polyadenylation Element (CPE) in the mRNAs 3\'UTR. It is found to express abnormally in multiple tumors and affect tumorigenesis through many pathways. This review summarizes the functions and mechanisms of CPEB1 in a variety of cancers and suggests new directions for future related treatments.
METHODS: A total of 95 articles were eligible for inclusion based on the year, quality of the research, and the strength of association with CPEB1. In this review, current research about how CPEB1 affects the initiation and progression of glioblastoma, breast cancer, hepatocellular carcinoma, gastric cancer, colorectal cancer, non-small cell lung cancer, prostate cancer, and melanoma are dissected, and the biomedical functions and mechanisms are summarized.
RESULTS: CPEB1 mostly presents as a tumor suppressor for breast cancer, endometrial carcinoma, hepatocellular carcinoma, non-small cell lung cancer, prostate cancer, and melanoma. However, glioblastoma, gastric cancer, and colorectal cancer it exhibit two opposing properties of tumorigenesis, either promoting or inhibiting it.
CONCLUSIONS: CPEB1 is likely to serve as a target and dynamic detection index or prognostic indicator for its function of apoptosis, activity, proliferation, migration, invasion, stemness, drug resistance, and even ferroptosis in various cancers.
METHODS: A total of 95 articles were eligible for inclusion based on the year, quality of the research, and the strength of association with CPEB1. In this review, current research about how CPEB1 affects the initiation and progression of glioblastoma, breast cancer, hepatocellular carcinoma, gastric cancer, colorectal cancer, non-small cell lung cancer, prostate cancer, and melanoma are dissected, and the biomedical functions and mechanisms are summarized.
RESULTS: CPEB1 mostly presents as a tumor suppressor for breast cancer, endometrial carcinoma, hepatocellular carcinoma, non-small cell lung cancer, prostate cancer, and melanoma. However, glioblastoma, gastric cancer, and colorectal cancer it exhibit two opposing properties of tumorigenesis, either promoting or inhibiting it.
CONCLUSIONS: CPEB1 is likely to serve as a target and dynamic detection index or prognostic indicator for its function of apoptosis, activity, proliferation, migration, invasion, stemness, drug resistance, and even ferroptosis in various cancers.
摘要：
背景：CPEB1是一种替代的聚腺苷酸化结合蛋白，通过与mRNA3'UTR中高度保守的细胞质聚腺苷酸化元件（CPE）结合来促进或抑制相关mRNA和蛋白质的表达。发现它在多种肿瘤中异常表达并通过许多途径影响肿瘤发生。本文总结了CPEB1在多种癌症中的作用和机制，并为未来的相关治疗提供了新的方向。
方法：根据年份，共有95篇文章符合纳入条件，研究的质量，以及与CPEB1的关联强度。在这次审查中,当前关于CPEB1如何影响胶质母细胞瘤的发生和进展的研究，乳腺癌,肝细胞癌，胃癌,结直肠癌,非小细胞肺癌,前列腺癌,黑色素瘤被解剖，并对其生物医学功能和机制进行了总结。
结果：CPEB1主要表现为乳腺癌的肿瘤抑制因子，子宫内膜癌,肝细胞癌，非小细胞肺癌,前列腺癌,还有黑色素瘤.然而,胶质母细胞瘤,胃癌,和结肠直肠癌它表现出两种相反的肿瘤发生特性，促进或抑制它。
结论：CPEB1可能作为其凋亡功能的靶点和动态检测指标或预后指标。活动,扩散,迁移,入侵,stemness,耐药性,甚至在各种癌症中的铁死亡。
方法：根据年份，共有95篇文章符合纳入条件，研究的质量，以及与CPEB1的关联强度。在这次审查中,当前关于CPEB1如何影响胶质母细胞瘤的发生和进展的研究，乳腺癌,肝细胞癌，胃癌,结直肠癌,非小细胞肺癌,前列腺癌,黑色素瘤被解剖，并对其生物医学功能和机制进行了总结。
结果：CPEB1主要表现为乳腺癌的肿瘤抑制因子，子宫内膜癌,肝细胞癌，非小细胞肺癌,前列腺癌,还有黑色素瘤.然而,胶质母细胞瘤,胃癌,和结肠直肠癌它表现出两种相反的肿瘤发生特性，促进或抑制它。
结论：CPEB1可能作为其凋亡功能的靶点和动态检测指标或预后指标。活动,扩散,迁移,入侵,stemness,耐药性,甚至在各种癌症中的铁死亡。
