METHODS: A total of 95 articles were eligible for inclusion based on the year, quality of the research, and the strength of association with CPEB1. In this review, current research about how CPEB1 affects the initiation and progression of glioblastoma, breast cancer, hepatocellular carcinoma, gastric cancer, colorectal cancer, non-small cell lung cancer, prostate cancer, and melanoma are dissected, and the biomedical functions and mechanisms are summarized.
RESULTS: CPEB1 mostly presents as a tumor suppressor for breast cancer, endometrial carcinoma, hepatocellular carcinoma, non-small cell lung cancer, prostate cancer, and melanoma. However, glioblastoma, gastric cancer, and colorectal cancer it exhibit two opposing properties of tumorigenesis, either promoting or inhibiting it.
CONCLUSIONS: CPEB1 is likely to serve as a target and dynamic detection index or prognostic indicator for its function of apoptosis, activity, proliferation, migration, invasion, stemness, drug resistance, and even ferroptosis in various cancers.
方法:根据年份,共有95篇文章符合纳入条件,研究的质量,以及与CPEB1的关联强度。在这次审查中,当前关于CPEB1如何影响胶质母细胞瘤的发生和进展的研究,乳腺癌,肝细胞癌,胃癌,结直肠癌,非小细胞肺癌,前列腺癌,黑色素瘤被解剖,并对其生物医学功能和机制进行了总结。
结果:CPEB1主要表现为乳腺癌的肿瘤抑制因子,子宫内膜癌,肝细胞癌,非小细胞肺癌,前列腺癌,还有黑色素瘤.然而,胶质母细胞瘤,胃癌,和结肠直肠癌它表现出两种相反的肿瘤发生特性,促进或抑制它。
结论:CPEB1可能作为其凋亡功能的靶点和动态检测指标或预后指标。活动,扩散,迁移,入侵,stemness,耐药性,甚至在各种癌症中的铁死亡。