PDF(Pubmed)
Abstract：
Exposure to ambient air pollution has significant adverse health effects; however, whether air pollution is associated with urological cancer is largely unknown. We conduct a systematic review and meta-analysis with epidemiological studies, showing that a 5 μg/m3 increase in PM2.5 exposure is associated with a 6%, 7%, and 9%, increased risk of overall urological, bladder, and kidney cancer, respectively; and a 10 μg/m3 increase in NO2 is linked to a 3%, 4%, and 4% higher risk of overall urological, bladder, and prostate cancer, respectively. Were these associations to reflect causal relationships, lowering PM2.5 levels to 5.8 μg/m3 could reduce the age-standardized rate of urological cancer by 1.5 ~ 27/100,000 across the 15 countries with the highest PM2.5 level from the top 30 countries with the highest urological cancer burden. Implementing global health policies that can improve air quality could potentially reduce the risk of urologic cancer and alleviate its burden.
摘要：
暴露于环境空气污染会对健康产生重大不利影响；然而，空气污染是否与泌尿系癌症相关在很大程度上是未知的。我们对流行病学研究进行了系统评价和荟萃分析，表明PM2.5暴露量增加5μg/m3与6%相关，7%,9%,整体泌尿外科的风险增加，膀胱,和肾癌，分别；NO2的10μg/m3增加与3%有关，4%,整体泌尿外科的风险高4%，膀胱,前列腺癌，分别。这些关联是否反映了因果关系，将PM2.5水平降低至5.8μg/m3可以将泌尿系统癌症的年龄标准化率降低1.5~27/100,000，其中PM2.5水平最高的15个国家是泌尿系统癌症负担最高的前30个国家。实施改善空气质量的全球卫生政策可能会降低泌尿系癌症的风险并减轻其负担。
