PDF(Pubmed)
Abstract：
OBJECTIVE: Bariatric surgery induces a significant loss of both fat mass (FM) and fat-free mass (FFM). The proteoglycan receptor syndecan-4 (SDC4) plays a crucial role in adipose tissue and skeletal muscle functions. Thus, this study was performed (i) to assess plasma SDC4 levels after both Sleeve Gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB) surgeries, and (ii) to explore potential associations with changes in body composition variables.
RESULTS: Twenty-six patients (17 females) with severe obesity underwent SG (n = 13) or RYGB (n = 13) and were followed up to 1 year (1Y). Body weight, FM, FFM, and SCD4 were measured at baseline (BL), and at week 11 (W11) and 1Y after surgery. Independently of procedure, there was a significant body weight loss at W11, with an average FM and FFM reduction of 13.7 ± 0.6 kg and 5.3 ± 0.5 kg, respectively. Participants continued to lose weight afterwards, with a total weigth loss of 38.2 ± 1.5 kg at 1Y. No associations were found at BL between SDC4 levels and any anthropometric variable; however, SDC4 levels were lower than BL at both W11 and 1Y, independently of type of surgery. Additionally, changes in SDC4 between BL and 1Y were positively correlated with weight and FFM loss during the same period.
BACKGROUND: ClinicalTrials.gov NCT04051190 on 09/08/2019.
RESULTS: Twenty-six patients (17 females) with severe obesity underwent SG (n = 13) or RYGB (n = 13) and were followed up to 1 year (1Y). Body weight, FM, FFM, and SCD4 were measured at baseline (BL), and at week 11 (W11) and 1Y after surgery. Independently of procedure, there was a significant body weight loss at W11, with an average FM and FFM reduction of 13.7 ± 0.6 kg and 5.3 ± 0.5 kg, respectively. Participants continued to lose weight afterwards, with a total weigth loss of 38.2 ± 1.5 kg at 1Y. No associations were found at BL between SDC4 levels and any anthropometric variable; however, SDC4 levels were lower than BL at both W11 and 1Y, independently of type of surgery. Additionally, changes in SDC4 between BL and 1Y were positively correlated with weight and FFM loss during the same period.
BACKGROUND: ClinicalTrials.gov NCT04051190 on 09/08/2019.
摘要：
目的：减重手术导致脂肪量（FM）和无脂肪量（FFM）的显著减少。蛋白聚糖受体syndecan-4（SDC4）在脂肪组织和骨骼肌功能中起着至关重要的作用。因此，进行这项研究（i）以评估袖状胃切除术（SG）和Roux-en-Y胃旁路术（RYGB）手术后的血浆SDC4水平，和（ii）探索与身体成分变量变化的潜在关联。
结果：26例重度肥胖患者（17例女性）接受SG（n=13）或RYGB（n=13）随访1年（1Y）。体重,FM,FFM,和SCD4在基线（BL）测量，手术后第11周（W11）和1Y。独立于程序，W11时体重明显下降，FM和FFM平均下降13.7±0.6kg和5.3±0.5kg，分别。参与者随后继续减肥，1Y时的总重量损失为38.2±1.5kg。在BL没有发现SDC4水平和任何人体测量变量之间的关联；然而，SDC4水平在W11和1Y均低于BL，与手术类型无关。此外,SDC4在BL和1Y之间的变化与同一时期的体重和FFM损失呈正相关。
背景：ClinicalTrials.govNCT04051190于2019年9月8日。
结果：26例重度肥胖患者（17例女性）接受SG（n=13）或RYGB（n=13）随访1年（1Y）。体重,FM,FFM,和SCD4在基线（BL）测量，手术后第11周（W11）和1Y。独立于程序，W11时体重明显下降，FM和FFM平均下降13.7±0.6kg和5.3±0.5kg，分别。参与者随后继续减肥，1Y时的总重量损失为38.2±1.5kg。在BL没有发现SDC4水平和任何人体测量变量之间的关联；然而，SDC4水平在W11和1Y均低于BL，与手术类型无关。此外,SDC4在BL和1Y之间的变化与同一时期的体重和FFM损失呈正相关。
背景：ClinicalTrials.govNCT04051190于2019年9月8日。
