Abstract:
Basaloid salivary gland neoplasms are a diverse and varied group of benign and malignant tumors. The term \'basaloid\' is broadly used in reference to cells with elevated nuclear to cytoplasmic ratio, sparse cytoplasm, and hyperchromatic nuclei. However, a subset may also fit within the \"small round blue cell tumor\" morphologic category or the \"biphasic\" salivary gland tumor category. Furthermore, there are no established thresholds for the proportion of basaloid tumor cells needed to consider a tumor within the basaloid spectrum. Given the implicit variability in what is considered a basaloid salivary gland tumor, one may question the inclusion of certain entities (canalicular adenoma, HMGA2::WIF1 pleomorphic adenoma, polymorphous adenocarcinoma) in this review based on classic morphologic features. However, salivary gland tumors with even minor basaloid components may appear \'basaloid\' in small biopsy specimens and, thus, a choice was made to focus on common and uncommon diagnostic differentials with this in mind. Entities that will be covered in this review also include basal cell adenoma and basal cell adenocarcinoma, adenoid cystic carcinoma, lymphoepithelial carcinoma, sialoblastoma, adamantinoma-like Ewing Sarcoma, NUT carcinoma, and carcinoma showing thymus-like differentiation.
摘要:
基底样涎腺肿瘤是良性和恶性肿瘤的多样性和多样性。术语“基底细胞样”广泛用于指核与细胞质比率升高的细胞,稀疏的细胞质,和超色核。然而,一个子集也可能符合“小圆蓝细胞肿瘤”形态学类别或“双相”唾液腺肿瘤类别。此外,对于在基底细胞谱内考虑肿瘤所需的基底细胞肿瘤细胞的比例,没有确定的阈值。考虑到基底样唾液腺肿瘤的内隐变异性,人们可能会质疑是否包括某些实体(泪小管腺瘤,HMGA2::WIF1多形性腺瘤,多形性腺癌)基于经典的形态学特征进行了综述。然而,唾液腺肿瘤甚至有轻微的基底细胞样成分可能出现在小活检标本中,因此,考虑到这一点,我们选择关注常见和不常见的诊断差异.本综述涵盖的实体还包括基底细胞腺瘤和基底细胞腺癌,腺样囊性癌,淋巴上皮癌,上皮母细胞瘤,金刚烷胺瘤样尤因肉瘤,NUT癌,和显示胸腺样分化的癌。