Abstract：
This paper investigates the relationship between periodontal disease and various cancer types. It provides a comprehensive overview of the existing knowledge about the interaction between periodontal disease and carcinogenesis, explores the underlying biological mechanisms of this connection, and consider the impact of these findings on healthcare practices and future research directions. Utilizing Systematic Literature Network Analysis, which combines bibliometric analysis with Systematic Literature Review, this study analyzes 164 documents from 2000 to 2023. Focus is placed on the 38 most globally cited papers, enabling a targeted and comprehensive analysis of the predominant research within this scope. This review highlights that colorectal, oral, pancreatic, lung, and gastrointestinal cancers have consistent associations with periodontal disease. On the other hand, hematological, breast and prostate cancers show associations with periodontal disease, but these links are less pronounced and more variable, indicating the need for targeted research in these domains. These insights emphasize the necessity for a multidisciplinary healthcare approach, recognizing the systemic implications of periodontal disease.
摘要：
本文研究了牙周病与各种癌症类型之间的关系。它提供了有关牙周病和致癌作用之间相互作用的现有知识的全面概述，探索这种联系的潜在生物学机制，并考虑这些发现对医疗保健实践和未来研究方向的影响。利用系统的文献网络分析，将文献计量分析与系统文献综述相结合，这项研究分析了2000年至2023年的164份文件。重点放在38篇全球引用最多的论文上，能够对这一范围内的主要研究进行有针对性和全面的分析。这篇综述强调了结直肠，口服,胰腺,肺，和胃肠道癌症与牙周病有一致的关联。另一方面,血液学,乳腺癌和前列腺癌与牙周病有关，但是这些联系不太明显，变量更大，这表明需要在这些领域进行有针对性的研究。这些见解强调了多学科医疗保健方法的必要性，认识到牙周病的系统性影响。
