Abstract：
BACKGROUND: Electroacupuncture (EA) could represent a clinically effective treatment strategy for patients with vascular cognitive impairment no dementia (VCIND). This randomized trial aims to explore the underlying mechanism of EA in VCIND patients through cognitive function assessment and neuroimaging assessment.
METHODS: 140 eligible patients with VCIND were recruited and randomly divided into EA group (n = 70) and Control group (n = 70). The Montreal Cognitive Assessment (MoCA), and the Auditory Verbal Learning Test (AVLT), the Stroop color-naming task (STROOP), and the resting-state functional magnetic resonance imaging assessment. The EA group received treatment for 30 min/day, 5 times/week, for 8 weeks.
RESULTS: EA intervention could increase the MoCA score and improve the neutral and consistency response of the STROOP test in VCIND patients (P < 0.05). fMRI functional connectivity analysis showed that, after EA, the default mode network (DMN) function of the posterior cingulate gyrus, left middle frontal gyrus, left anterior cingulate gyrus, left and right superior temporal gyrus, right insula, left precentral gyrus and other brain regions were significantly higher than that in the control group. The functional connectivity between the posterior cingulate gyrus-left middle frontal gyrus and the posterior cingulate gyrus-right superior temporal gyrus was positively correlated with cognitive function (P < 0.05). Gray Matter Volume increased in VCIND after EA(P < 0.05).
CONCLUSIONS: EA can increase the functional connectivity between posterior cingulate gyrus-other gyri in VCIND patients. The functional connectivity is positively correlated with cognitive function.
METHODS: 140 eligible patients with VCIND were recruited and randomly divided into EA group (n = 70) and Control group (n = 70). The Montreal Cognitive Assessment (MoCA), and the Auditory Verbal Learning Test (AVLT), the Stroop color-naming task (STROOP), and the resting-state functional magnetic resonance imaging assessment. The EA group received treatment for 30 min/day, 5 times/week, for 8 weeks.
RESULTS: EA intervention could increase the MoCA score and improve the neutral and consistency response of the STROOP test in VCIND patients (P < 0.05). fMRI functional connectivity analysis showed that, after EA, the default mode network (DMN) function of the posterior cingulate gyrus, left middle frontal gyrus, left anterior cingulate gyrus, left and right superior temporal gyrus, right insula, left precentral gyrus and other brain regions were significantly higher than that in the control group. The functional connectivity between the posterior cingulate gyrus-left middle frontal gyrus and the posterior cingulate gyrus-right superior temporal gyrus was positively correlated with cognitive function (P < 0.05). Gray Matter Volume increased in VCIND after EA(P < 0.05).
CONCLUSIONS: EA can increase the functional connectivity between posterior cingulate gyrus-other gyri in VCIND patients. The functional connectivity is positively correlated with cognitive function.
摘要：
背景：电针（EA）可以代表无痴呆（VCIND）的血管性认知障碍患者的临床有效治疗策略。这项随机试验旨在通过认知功能评估和神经影像学评估来探索VCIND患者EA的潜在机制。
方法：纳入140例VCIND患者，随机分为电针组（n=70）和对照组（n=70）。蒙特利尔认知评估（MoCA）和听觉语言学习测试（AVLT），Stroop颜色命名任务（STROOP），和静息态功能磁共振成像评估。EA组接受30分钟/天的治疗，5次/周,八个星期。
结果：EA干预可提高VCIND患者MoCA评分，改善STROOP试验的中性和一致性反应（P<0.05）。功能磁共振功能连接分析显示,EA之后,后扣带回的默认模式网络（DMN）功能，左额中回,左前扣带回,左右颞上回,右岛，左中央前回和其他脑区明显高于对照组。后扣带回-左额中回和后扣带回-右颞上回的功能连接与认知功能呈正相关(P<0.05)。EA后VCIND的灰质体积增加（P<0.05）。
结论：电针可以增加VCIND患者后扣带回-其他回之间的功能连接。功能连接与认知功能呈正相关。
方法：纳入140例VCIND患者，随机分为电针组（n=70）和对照组（n=70）。蒙特利尔认知评估（MoCA）和听觉语言学习测试（AVLT），Stroop颜色命名任务（STROOP），和静息态功能磁共振成像评估。EA组接受30分钟/天的治疗，5次/周,八个星期。
结果：EA干预可提高VCIND患者MoCA评分，改善STROOP试验的中性和一致性反应（P<0.05）。功能磁共振功能连接分析显示,EA之后,后扣带回的默认模式网络（DMN）功能，左额中回,左前扣带回,左右颞上回,右岛，左中央前回和其他脑区明显高于对照组。后扣带回-左额中回和后扣带回-右颞上回的功能连接与认知功能呈正相关(P<0.05)。EA后VCIND的灰质体积增加（P<0.05）。
结论：电针可以增加VCIND患者后扣带回-其他回之间的功能连接。功能连接与认知功能呈正相关。
