UNASSIGNED: To design therapies to combat CLD, it is essential to consider the dysregulation of other tissues that contribute to its development and progression. As such, proper therapies must combat this throughout the body rather than focusing only on the liver. To detail this, literature characterizing the pathogenesis of CLD was pulled from PubMed, with a particular focus placed on the role of PDE4 in inflammation and metabolism. Then, the focus is shifted to detailing the available information on existing PDE4 inhibitors.
UNASSIGNED: This review gives a brief overview of some of the pathologies of organ systems that are distinct from the liver but contribute to disease progression. The demonstrated efficacy of PDE4 inhibitors in other human inflammatory diseases should earn them further examination for the treatment of CLD.
■为了设计对抗CLD的疗法,必须考虑其他组织的失调,这有助于其发展和进展。因此,适当的治疗必须在整个身体中对抗这种情况,而不是只关注肝脏。要详细说明这一点,描述CLD发病机理的文献来自PubMed,特别关注PDE4在炎症和代谢中的作用。然后,重点转移到详述现有PDE4抑制剂的可用信息。
■这篇综述简要概述了一些与肝脏不同但有助于疾病进展的器官系统病理。PDE4抑制剂在其他人类炎性疾病中的已证实的功效应该使他们进一步检查CLD的治疗。