Abstract：
BACKGROUND: The association between psoriasis and hyperthyroidism/hypothyroidism remains inconclusive, with conflicting findings in prior studies.
OBJECTIVE: This study employs Mendelian randomization methods to assess the potential relationship.
METHODS: Given the inability to accurately observe the link between psoriasis and thyroid dysfunction, we prioritized utilizing known genetic variants to investigate the potential impacts of the disease.We analyzed data from genome-wide association studies (GWASs), FinnGen, and UK Biobank to extract information on psoriasis, hyperthyroidism, and hypothyroidism. Three MR approaches (MR Egger, weighted median, and inverse variance weighted) were used to scrutinize the causal link.
RESULTS: Our analysis revealed no correlation between psoriasis and hyperthyroidism/hypothyroidism. However, vulgar psoriasis and guttate psoriasis were associated with hypothyroidism/myxedema (IVW odds ratio (OR) = 1.00, 95% confidence interval (CI) = 1.00-1.00, P = 2.53E-03), and Graves\' disease (IVW OR = 0.86, 95% CI = 0.72-1.01, P = 4.75E-02).In a subsequent analysis, we observed that hypothyroidism with mucinous edema showed no correlation with Graves\' disease in the opposite(P = 9.33E-01).
CONCLUSIONS: This MR analysis suggests no association between psoriasis and thyroid dysfunction, but highlights associations of vulgar/guttate psoriasis with hypothyroidism/myxedema and Graves\' disease. In clinical practice, diagnosing guttate psoriasis requires vigilance for associated risks from hypothyroidism and Graves\' disease. For patients with both vulgar psoriasis and hypothyroidism, careful monitoring for mucinous edema is crucial, as it may signal a hypothyroid crisis.
OBJECTIVE: This study employs Mendelian randomization methods to assess the potential relationship.
METHODS: Given the inability to accurately observe the link between psoriasis and thyroid dysfunction, we prioritized utilizing known genetic variants to investigate the potential impacts of the disease.We analyzed data from genome-wide association studies (GWASs), FinnGen, and UK Biobank to extract information on psoriasis, hyperthyroidism, and hypothyroidism. Three MR approaches (MR Egger, weighted median, and inverse variance weighted) were used to scrutinize the causal link.
RESULTS: Our analysis revealed no correlation between psoriasis and hyperthyroidism/hypothyroidism. However, vulgar psoriasis and guttate psoriasis were associated with hypothyroidism/myxedema (IVW odds ratio (OR) = 1.00, 95% confidence interval (CI) = 1.00-1.00, P = 2.53E-03), and Graves\' disease (IVW OR = 0.86, 95% CI = 0.72-1.01, P = 4.75E-02).In a subsequent analysis, we observed that hypothyroidism with mucinous edema showed no correlation with Graves\' disease in the opposite(P = 9.33E-01).
CONCLUSIONS: This MR analysis suggests no association between psoriasis and thyroid dysfunction, but highlights associations of vulgar/guttate psoriasis with hypothyroidism/myxedema and Graves\' disease. In clinical practice, diagnosing guttate psoriasis requires vigilance for associated risks from hypothyroidism and Graves\' disease. For patients with both vulgar psoriasis and hypothyroidism, careful monitoring for mucinous edema is crucial, as it may signal a hypothyroid crisis.
摘要：
背景：银屑病与甲状腺功能亢进/甲状腺功能减退症之间的关系尚无定论，与先前研究中的发现相矛盾。
目的：本研究采用孟德尔随机化方法来评估潜在的关系。
方法：由于无法准确观察银屑病与甲状腺功能异常之间的联系，我们优先考虑利用已知的遗传变异来研究该疾病的潜在影响.我们分析了来自全基因组关联研究(GWAS)的数据，FinnGen,和英国生物银行来提取牛皮癣的信息，甲状腺功能亢进,和甲状腺功能减退。三种MR方法(MREgger，加权中位数，和逆方差加权)用于仔细检查因果联系。
结果：我们的分析显示银屑病与甲状腺功能亢进/甲状腺功能减退无相关性。然而,寻常型银屑病和点滴型银屑病与甲状腺功能减退/粘液水肿相关(IVW比值比(OR)=1.00,95%可信区间(CI)=1.00-1.00,P=2.53E-03),和Graves病（IVWOR=0.86，95%CI=0.72-1.01，P=4.75E-02）。在随后的分析中，我们观察到甲状腺功能减退症伴黏液性水肿与Graves病的相关性相反(P=9.33E-01)。
结论：这项MR分析提示银屑病与甲状腺功能异常无关，但强调了低俗/点滴状银屑病与甲状腺功能减退/粘液水肿和Graves病的关联。在临床实践中,诊断点滴状银屑病需要警惕甲状腺功能减退和Graves病的相关风险。对于患有寻常性银屑病和甲状腺功能减退症的患者，仔细监测粘液性水肿至关重要，因为它可能预示着甲状腺功能减退的危象.
目的：本研究采用孟德尔随机化方法来评估潜在的关系。
方法：由于无法准确观察银屑病与甲状腺功能异常之间的联系，我们优先考虑利用已知的遗传变异来研究该疾病的潜在影响.我们分析了来自全基因组关联研究(GWAS)的数据，FinnGen,和英国生物银行来提取牛皮癣的信息，甲状腺功能亢进,和甲状腺功能减退。三种MR方法(MREgger，加权中位数，和逆方差加权)用于仔细检查因果联系。
结果：我们的分析显示银屑病与甲状腺功能亢进/甲状腺功能减退无相关性。然而,寻常型银屑病和点滴型银屑病与甲状腺功能减退/粘液水肿相关(IVW比值比(OR)=1.00,95%可信区间(CI)=1.00-1.00,P=2.53E-03),和Graves病（IVWOR=0.86，95%CI=0.72-1.01，P=4.75E-02）。在随后的分析中，我们观察到甲状腺功能减退症伴黏液性水肿与Graves病的相关性相反(P=9.33E-01)。
结论：这项MR分析提示银屑病与甲状腺功能异常无关，但强调了低俗/点滴状银屑病与甲状腺功能减退/粘液水肿和Graves病的关联。在临床实践中,诊断点滴状银屑病需要警惕甲状腺功能减退和Graves病的相关风险。对于患有寻常性银屑病和甲状腺功能减退症的患者，仔细监测粘液性水肿至关重要，因为它可能预示着甲状腺功能减退的危象.
