Abstract：
In an age of cutting-edge sequencing methods and worldwide endeavors such as The Human Microbiome Project and MetaHIT, the human microbiome stands as a complex and diverse community of microorganisms. A central theme in current scientific inquiry revolves around reinstating a balanced microbial composition, referred to as \"eubiosis,\" as a targeted approach for treating vast array of diseases. Vaginal Microbiota Transplantation (VMT), inspired by the success of fecal microbiota transplantation, emerges as an innovative therapy addressing vaginal dysbacteriosis by transferring the complete microbiota from a healthy donor. Antibiotics, while effective, pose challenges with adverse effects, high recurrence rates, and potential harm to beneficial Lactobacillus strains. Continued antibiotic usage also sparks worries regarding the development of resistant strains. Probiotics, though showing promise, exhibit inconsistency in treating multifactorial diseases, and concerns linger about their suitability for diverse genetic backgrounds. Given the recurrent challenges associated with antibiotic and probiotic treatments, VMT emerges as an imperative alternative, offering a unique and promising avenue for efficiently and reliably managing vaginal dysbiosis among a majority of women. This review critically evaluates findings from both animal and human studies, offering nuanced insights into the efficacy and challenges of VMT. An extensive analysis of clinical trials, provides a current overview of ongoing and completed trials, shedding light on the evolving clinical landscape and therapeutic potential of VMT. Delving into the origins, mechanisms, and optimized protocols of VMT, the review underscores the imperative for sustained research efforts to advance this groundbreaking gynecological therapy.
摘要：
在尖端测序方法和全球努力的时代，如人类微生物组项目和MetaHIT，人类微生物组是一个复杂多样的微生物群落。当前科学研究的中心主题围绕着恢复平衡的微生物组成，被称为“优生物”，“作为治疗各种疾病的有针对性的方法。阴道微生物移植（VMT），受粪便微生物移植成功的启发，通过从健康供体转移完整的微生物群来解决阴道菌群失调的创新疗法。抗生素,虽然有效，带来不利影响的挑战，高复发率,以及对有益乳酸菌菌株的潜在危害。持续使用抗生素也引发了人们对耐药菌株发展的担忧。益生菌,虽然显示出希望，在治疗多因素疾病方面表现出不一致，并担心它们是否适合不同的遗传背景。鉴于与抗生素和益生菌治疗相关的经常性挑战，VMT作为一种必要的替代方案出现，提供了一个独特的和有前途的途径，有效和可靠地管理阴道菌群失调的大多数妇女。这篇综述批判性地评估了动物和人类研究的结果，为VMT的功效和挑战提供细致入微的见解。对临床试验的广泛分析，提供了正在进行和已完成的试验的当前概述，揭示VMT不断发展的临床景观和治疗潜力。深入研究起源，机制,和优化的VMT协议，该综述强调了持续的研究努力以推进这一开创性的妇科治疗的必要性.
