Abstract：
Stimuli-responsive adhesives with on-demand adhesion capabilities are highly advantageous for facilitating wound healing. However, the triggering conditions of stimuli-responsive adhesives are cumbersome, even though some of them are detrimental to the adhesive and adjacent natural tissues. Herein, a novel stimuli-responsive adhesive called shear-stiffening adhesive (SSA) has been created by constructing a poly(diborosiloxane)-based silicone network for the first time, and SSA exhibits a rate-responsive adhesion behavior. Furthermore, we introduced bactericidal factors (PVP-I) into SSA and applied it as a wound dressing to promote the healing of infected wounds. Impressively, the wound dressing not only has excellent biocompatibility and long-term antibacterial properties but also performs well in accelerating wound healing. Therefore, this study provides a new strategy for the synthesis of intelligent adhesives with force rate response, which simplifies the triggering conditions by the force rate. Thus, SSA has great potential to be applied in wound management as an intelligent bioadhesive with on-demand adhesion performance.
摘要：
具有按需粘附能力的刺激响应性粘合剂对于促进伤口愈合是非常有利的。然而,刺激响应性粘合剂的触发条件很麻烦，即使其中一些对粘合剂和邻近的自然组织有害。在这里，通过首次构建基于聚（二硼硅氧烷）的有机硅网络，创建了一种称为剪切硬化粘合剂（SSA）的新型刺激响应性粘合剂，和SSA表现出速率响应性粘附行为。此外，我们将杀菌因子（PVP-I）引入SSA，并将其用作伤口敷料以促进感染伤口的愈合。令人印象深刻的是,该伤口敷料不仅具有优异的生物相容性和长期抗菌性能，而且在促进伤口愈合方面表现良好。因此,本研究为具有力速率响应的智能胶粘剂的合成提供了一种新的策略,这通过力率简化了触发条件。因此，SSA作为一种具有按需粘附性能的智能生物粘合剂，具有很大的应用于伤口管理的潜力。
