Abstract：
BACKGROUND: This systematic review and meta-analysis aimed to evaluate the overall impact of Panax ginseng on lipid profile by synthesizing existing evidence. Cardiovascular Disease (CVD) is the leading cause of morbidity and mortality among the elderly population, and serum lipids play a crucial role in its development. Maintaining optimal levels of triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total cholesterol is essential in reducing the risk of CVD. Ginsenosides, the active constituents in ginseng, have shown positive effects on lipid metabolism. This review aimed to provide a comprehensive understanding of the potential benefits of ginseng in managing dyslipidemia, which could have significant implications for the prevention and treatment of CVD.
METHODS: A comprehensive analysis of 29 Randomized Controlled Trials (RCTs) was conducted to assess the effects of ginseng supplementation on lipid profile, including Triglyceride (TG), Total Cholesterol (TC), High- -density Lipoprotein Cholesterol (HDL-C), and Low-density Lipoprotein Cholesterol (LDL-C) levels. A systematic search was done in online databases, such as MEDLINE, Scopus, and Clarivate Analytics Web of Science, using relevant keywords and MeSH terms to identify relevant studies until January 2024.
RESULTS: The Weighted Mean Differences (WMD) and 95% Confidence Intervals (CI) for TG, TC, LDL-C, and HDL-C did not show significant changes with ginseng supplementation.
CONCLUSIONS: Taking into account the results, using ginseng did not have a statistically significant influence on lipid profile parameters in individuals with different health conditions. Further, well-designed RCTs focusing on specific diseases are needed to clarify the potential beneficial effects of ginseng and its derivatives on lipid profile.
METHODS: A comprehensive analysis of 29 Randomized Controlled Trials (RCTs) was conducted to assess the effects of ginseng supplementation on lipid profile, including Triglyceride (TG), Total Cholesterol (TC), High- -density Lipoprotein Cholesterol (HDL-C), and Low-density Lipoprotein Cholesterol (LDL-C) levels. A systematic search was done in online databases, such as MEDLINE, Scopus, and Clarivate Analytics Web of Science, using relevant keywords and MeSH terms to identify relevant studies until January 2024.
RESULTS: The Weighted Mean Differences (WMD) and 95% Confidence Intervals (CI) for TG, TC, LDL-C, and HDL-C did not show significant changes with ginseng supplementation.
CONCLUSIONS: Taking into account the results, using ginseng did not have a statistically significant influence on lipid profile parameters in individuals with different health conditions. Further, well-designed RCTs focusing on specific diseases are needed to clarify the potential beneficial effects of ginseng and its derivatives on lipid profile.
摘要：
背景：本系统综述和荟萃分析旨在通过综合现有证据来评估人参对血脂谱的总体影响。心血管疾病(CVD)是老年人群发病和死亡的主要原因,和血脂在其发展中起着至关重要的作用。保持最佳的甘油三酯水平，高密度脂蛋白胆固醇，低密度脂蛋白胆固醇，总胆固醇对降低心血管疾病的风险至关重要。人参皂苷,人参中的活性成分，对脂质代谢有积极影响。这篇综述旨在全面了解人参在治疗血脂异常中的潜在益处。这可能对预防和治疗心血管疾病具有重要意义。
方法：对29个随机对照试验（RCT）进行了综合分析，以评估人参补充剂对血脂的影响，包括甘油三酯（TG），总胆固醇（TC），高密度脂蛋白胆固醇(HDL-C),和低密度脂蛋白胆固醇（LDL-C）水平。在在线数据库中进行了系统的搜索，比如MEDLINE,Scopus,和ClarivateAnalyticsWebofScience，使用相关关键词和MeSH术语来确定2024年1月之前的相关研究。
结果：TG的加权平均差（WMD）和95％置信区间（CI），TC,LDL-C,补充人参后，HDL-C没有显着变化。
结论：考虑到结果，在不同健康状况的个体中，使用人参对血脂参数没有统计学意义的影响。Further,需要针对特定疾病的精心设计的随机对照试验,以阐明人参及其衍生物对血脂谱的潜在有益作用.
方法：对29个随机对照试验（RCT）进行了综合分析，以评估人参补充剂对血脂的影响，包括甘油三酯（TG），总胆固醇（TC），高密度脂蛋白胆固醇(HDL-C),和低密度脂蛋白胆固醇（LDL-C）水平。在在线数据库中进行了系统的搜索，比如MEDLINE,Scopus,和ClarivateAnalyticsWebofScience，使用相关关键词和MeSH术语来确定2024年1月之前的相关研究。
结果：TG的加权平均差（WMD）和95％置信区间（CI），TC,LDL-C,补充人参后，HDL-C没有显着变化。
结论：考虑到结果，在不同健康状况的个体中，使用人参对血脂参数没有统计学意义的影响。Further,需要针对特定疾病的精心设计的随机对照试验,以阐明人参及其衍生物对血脂谱的潜在有益作用.
