Abstract：
Hepatitis E virus (HEV) is the major pathogen of viral hepatitis. Immunocompromised individuals infected by HEV are prone to chronic hepatitis and increase the risk of hepato-cellular carcinoma (HCC). Inhibitor of growth family member 5 (ING5) is a tumor suppressor that is expressed at low levels in cancer tumors or cells. However, the underlying relationship between ING5 and HEV infection is unclear. In the present study, acute and chronic HEV animal models are used to explore the interaction between ING5 and HEV. Notably, the expression of ING5 is significantly increased in both the livers of acute HEV-infected BALB/c mice and chronic HEV-infected rhesus macaques. In addition, the relationship between HEV infection and ING5 expression is further identified in human hepatoma (HepG-2) cells. In conclusion, HEV infection strongly upregulates ING5 expression both in vivo and in vitro, which has significant implications for further understanding the pathogenic mechanism of HEV infection.
摘要：
戊型肝炎病毒(HEV)是病毒性肝炎的主要病原。受HEV感染的免疫功能低下的个体容易患慢性肝炎，并增加肝细胞癌（HCC）的风险。生长抑制剂家族成员5(ING5)是在癌症肿瘤或细胞中以低水平表达的肿瘤抑制剂。然而,ING5与HEV感染之间的潜在关系尚不清楚.在本研究中,急性和慢性HEV动物模型用于探索ING5和HEV之间的相互作用。值得注意的是,在急性HEV感染的BALB/c小鼠和慢性HEV感染的恒河猴的肝脏中，ING5的表达均显着增加。此外,在人肝癌（HepG-2）细胞中进一步鉴定了HEV感染与ING5表达之间的关系。总之,HEV感染在体内和体外强烈上调ING5表达，这对于进一步了解HEV感染的致病机制具有重要意义。
