Abstract：
Candida species, commensal residents of human skin, are recognized as the cause of cutaneous candidiasis across various body surfaces. Individuals with weakened immune systems, particularly those with immunosuppressive conditions, are significantly more susceptible to this infection. Diabetes mellitus, a major metabolic disorder, has emerged as a critical factor inducing immunosuppression, thereby facilitating Candida colonization and subsequent skin infections. This comprehensive review examines the prevalence of different types of Candida albicans-induced cutaneous candidiasis in diabetic patients. It explores the underlying mechanisms of pathogenicity and offers insights into recommended preventive measures and treatment strategies. Diabetes notably increases vulnerability to oral and oesophageal candidiasis. Additionally, it can precipitate vulvovaginal candidiasis in females, Candida balanitis in males, and diaper candidiasis in young children with diabetes. Diabetic individuals may also experience candidal infections on their nails, hands and feet. Notably, diabetes appears to be a risk factor for intertrigo syndrome in obese individuals and periodontal disorders in denture wearers. In conclusion, the intricate relationship between diabetes and cutaneous candidiasis necessitates a comprehensive understanding to strategize effective management planning. Further investigation and interdisciplinary collaborative efforts are crucial to address this multifaceted challenge and uncover novel approaches for the treatment, management and prevention of both health conditions, including the development of safer and more effective antifungal agents.
摘要：
念珠菌,人类皮肤的共生居民，被认为是各种身体表面皮肤念珠菌病的原因。免疫系统较弱的人，特别是那些有免疫抑制症状的人，更容易受到这种感染。糖尿病,一种主要的代谢紊乱,已经成为诱导免疫抑制的关键因素，从而促进念珠菌定植和随后的皮肤感染。这篇全面的综述研究了糖尿病患者中不同类型的白色念珠菌引起的皮肤念珠菌病的患病率。它探讨了致病性的潜在机制，并提供了建议的预防措施和治疗策略的见解。糖尿病显著增加口腔和食道念珠菌病的易感性。此外,它可以导致女性外阴阴道念珠菌病，男性念珠菌龟头炎,糖尿病患儿的尿布念珠菌病。糖尿病个体也可能在他们的指甲上经历念珠菌感染，手和脚。值得注意的是,糖尿病似乎是肥胖者中的intertrigo综合征和义齿佩戴者中的牙周病的危险因素。总之,糖尿病和皮肤念珠菌病之间错综复杂的关系需要全面了解以制定有效的管理计划。进一步的调查和跨学科的合作努力对于解决这一多方面的挑战和发现新的治疗方法至关重要。管理和预防两种健康状况，包括开发更安全、更有效的抗真菌药物。
