PDF(Pubmed)
Abstract：
BACKGROUND: Lynch syndrome is the most common cause of hereditary colorectal and endometrial cancer. Lifestyle modification may provide an opportunity for adjunctive cancer prevention. In this study, we aimed to characterise modifiable risk factors in people with Lynch syndrome and compare this with international guidelines for cancer prevention.
METHODS: A cross-sectional study was carried out utilizing survey methodology. Following public and patient involvement, the survey was disseminated through patient advocacy groups and by social media. Self-reported demographic and health behaviours were collected in April 2023. Guidelines from the World Cancer Research Fund (WCRF) were used to compare percentage adherence to 9 lifestyle recommendations, including diet, physical activity, weight, and alcohol intake. Median adherence scores, as a surrogate for lifestyle risk, were calculated and compared between groups.
RESULTS: 156 individuals with Lynch syndrome participated from 13 countries. The median age was 51, and 54% were cancer survivors. The mean BMI was 26.7 and the mean weekly duration of moderate to vigorous physical activity was 90 min. Median weekly consumption of ethanol was 60 g, and 3% reported current smoking. Adherence to WCRF recommendations for cancer prevention ranged from 9 to 73%, with all but one recommendation having < 50% adherence. The median adherence score was 2.5 out of 7. There was no significant association between median adherence scores and age (p = 0.27), sex (p = 0.31), or cancer history (p = 0.75).
CONCLUSIONS: We have characterised the modifiable risk profile of people living with Lynch syndrome, outlining targets for intervention based on lifestyle guidelines for the general population. As evidence supporting the relevance of modifiable factors in Lynch syndrome emerges, behavioural modification may prove an impactful means of cancer prevention.
METHODS: A cross-sectional study was carried out utilizing survey methodology. Following public and patient involvement, the survey was disseminated through patient advocacy groups and by social media. Self-reported demographic and health behaviours were collected in April 2023. Guidelines from the World Cancer Research Fund (WCRF) were used to compare percentage adherence to 9 lifestyle recommendations, including diet, physical activity, weight, and alcohol intake. Median adherence scores, as a surrogate for lifestyle risk, were calculated and compared between groups.
RESULTS: 156 individuals with Lynch syndrome participated from 13 countries. The median age was 51, and 54% were cancer survivors. The mean BMI was 26.7 and the mean weekly duration of moderate to vigorous physical activity was 90 min. Median weekly consumption of ethanol was 60 g, and 3% reported current smoking. Adherence to WCRF recommendations for cancer prevention ranged from 9 to 73%, with all but one recommendation having < 50% adherence. The median adherence score was 2.5 out of 7. There was no significant association between median adherence scores and age (p = 0.27), sex (p = 0.31), or cancer history (p = 0.75).
CONCLUSIONS: We have characterised the modifiable risk profile of people living with Lynch syndrome, outlining targets for intervention based on lifestyle guidelines for the general population. As evidence supporting the relevance of modifiable factors in Lynch syndrome emerges, behavioural modification may prove an impactful means of cancer prevention.
摘要：
背景：林奇综合征是遗传性结直肠癌和子宫内膜癌的最常见原因。生活方式的改变可能为辅助癌症预防提供机会。在这项研究中,我们旨在描述Lynch综合征患者的可改变危险因素,并将其与国际癌症预防指南进行比较.
方法：采用调查方法进行了横断面研究。在公众和患者参与之后，该调查通过患者倡导团体和社交媒体进行传播.2023年4月收集了自我报告的人口和健康行为。使用世界癌症研究基金会（WCRF）的指南来比较9种生活方式建议的依从性百分比。包括饮食,身体活动,体重,酒精摄入量。依从性得分中位数，作为生活方式风险的替代品，进行计算和组间比较。
结果：来自13个国家的156名Lynch综合征患者参与。中位年龄为51岁，54%为癌症幸存者。平均BMI为26.7，中度至剧烈体力活动的平均每周持续时间为90分钟。乙醇的每周平均消耗量为60g，3%报告目前吸烟。对WCRF关于癌症预防的建议的依从性从9%到73%不等。除一项建议外，所有建议的依从性均<50%。中位依从性评分为7分的2.5分。中位依从性评分和年龄之间没有显著关联（p=0.27），性别（p=0.31），或癌症病史（p=0.75）。
结论：我们已经确定了林奇综合征患者的可改变风险特征，概述基于一般人群生活方式指南的干预目标。随着支持林奇综合征中可改变因素相关性的证据的出现，行为改变可能是一种有效的癌症预防手段。
方法：采用调查方法进行了横断面研究。在公众和患者参与之后，该调查通过患者倡导团体和社交媒体进行传播.2023年4月收集了自我报告的人口和健康行为。使用世界癌症研究基金会（WCRF）的指南来比较9种生活方式建议的依从性百分比。包括饮食,身体活动,体重,酒精摄入量。依从性得分中位数，作为生活方式风险的替代品，进行计算和组间比较。
结果：来自13个国家的156名Lynch综合征患者参与。中位年龄为51岁，54%为癌症幸存者。平均BMI为26.7，中度至剧烈体力活动的平均每周持续时间为90分钟。乙醇的每周平均消耗量为60g，3%报告目前吸烟。对WCRF关于癌症预防的建议的依从性从9%到73%不等。除一项建议外，所有建议的依从性均<50%。中位依从性评分为7分的2.5分。中位依从性评分和年龄之间没有显著关联（p=0.27），性别（p=0.31），或癌症病史（p=0.75）。
结论：我们已经确定了林奇综合征患者的可改变风险特征，概述基于一般人群生活方式指南的干预目标。随着支持林奇综合征中可改变因素相关性的证据的出现，行为改变可能是一种有效的癌症预防手段。
