PDF(Pubmed)
Abstract：
BACKGROUND: Coronary artery disease (CAD) is known as the leading cause of disability and death globally. Anxiety disorders are also recognized as common types of mental disorders that substantially impact global health. Iran ranks among the countries with a high incidence of CAD and anxiety disorders. Therefore, the present study aims to determine the potential association and epidemiological aspects of anxiety and CAD within the population of Mashhad, the second most popoulos city in Iran.
METHODS: The present study is based on extracted data from the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study which is a 10-year prospective cohort study intended to assess the effects of various CAD risk factors among Mashhad city residents. Anxiety scores were assessed at the baseline using Beck Anxiety Inventory and individuals were classified based on the BAI 4-factor structure model which included autonomic, cognitive, panic, and neuromotor components. Accordingly, the association between baseline anxiety scores and the BAI four-factor model with the risk of CAD events was analyzed using SPSS software version 21.
RESULTS: Based on the results, 60.4% of the sample were female, and 5.6% were classified as having severe forms of anxiety. Moreover, severe anxiety was more prevalent in females. Results showed a 1.7% risk of CAD (p-value < 0.001) over 10 years with one unit increase in anxiety score. Based on the 4-factor model structure, we found that only panic disorder could significantly increase the risk of CAD by 1.1% over the 10-year follow-up (p-value < 0.001).
CONCLUSIONS: Anxiety symptoms, particularly panic disorder, are independently and significantly associated with an increased overall risk of developing CAD over a 10-year period. Therefore, further studies are warranted to investigate the mechanisms through which anxiety may cause CAD, as well as possible interventions to mitigate these processes.
METHODS: The present study is based on extracted data from the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study which is a 10-year prospective cohort study intended to assess the effects of various CAD risk factors among Mashhad city residents. Anxiety scores were assessed at the baseline using Beck Anxiety Inventory and individuals were classified based on the BAI 4-factor structure model which included autonomic, cognitive, panic, and neuromotor components. Accordingly, the association between baseline anxiety scores and the BAI four-factor model with the risk of CAD events was analyzed using SPSS software version 21.
RESULTS: Based on the results, 60.4% of the sample were female, and 5.6% were classified as having severe forms of anxiety. Moreover, severe anxiety was more prevalent in females. Results showed a 1.7% risk of CAD (p-value < 0.001) over 10 years with one unit increase in anxiety score. Based on the 4-factor model structure, we found that only panic disorder could significantly increase the risk of CAD by 1.1% over the 10-year follow-up (p-value < 0.001).
CONCLUSIONS: Anxiety symptoms, particularly panic disorder, are independently and significantly associated with an increased overall risk of developing CAD over a 10-year period. Therefore, further studies are warranted to investigate the mechanisms through which anxiety may cause CAD, as well as possible interventions to mitigate these processes.
摘要：
背景：冠状动脉疾病（CAD）在全球范围内被认为是导致残疾和死亡的主要原因。焦虑症也被认为是严重影响全球健康的常见类型的精神障碍。伊朗是CAD和焦虑症发病率高的国家之一。因此,本研究旨在确定马什哈德人群中焦虑和CAD的潜在关联和流行病学方面，伊朗第二大的波普洛斯市。
方法：本研究基于Mashhad卒中和心脏动脉粥样硬化疾病（MASHAD）研究的数据，MASHAD是一项为期10年的前瞻性队列研究，旨在评估各种CAD风险因素在Mashhad城市居民中的影响。使用贝克焦虑量表在基线时评估焦虑评分，并根据BAI4因素结构模型对个体进行分类，其中包括自主神经，认知，恐慌，和神经运动组件。因此，使用SPSS软件版本21分析基线焦虑评分和BAI四因素模型与CAD事件风险之间的关联.
结果：根据结果，60.4%的样本是女性，5.6%被归类为患有严重形式的焦虑。此外，严重焦虑在女性中更为普遍。结果显示，10年内CAD的风险为1.7％（p值<0.001），焦虑评分增加一个单位。基于4因素模型结构，我们发现,在10年的随访中,只有惊恐障碍可使CAD风险显著增加1.1%(p值<0.001).
结论：焦虑症状，尤其是恐慌症，在10年的时间内，与发展CAD的总体风险增加独立且显着相关。因此,需要进一步的研究来研究焦虑可能导致CAD的机制，以及缓解这些过程的可能干预措施。
方法：本研究基于Mashhad卒中和心脏动脉粥样硬化疾病（MASHAD）研究的数据，MASHAD是一项为期10年的前瞻性队列研究，旨在评估各种CAD风险因素在Mashhad城市居民中的影响。使用贝克焦虑量表在基线时评估焦虑评分，并根据BAI4因素结构模型对个体进行分类，其中包括自主神经，认知，恐慌，和神经运动组件。因此，使用SPSS软件版本21分析基线焦虑评分和BAI四因素模型与CAD事件风险之间的关联.
结果：根据结果，60.4%的样本是女性，5.6%被归类为患有严重形式的焦虑。此外，严重焦虑在女性中更为普遍。结果显示，10年内CAD的风险为1.7％（p值<0.001），焦虑评分增加一个单位。基于4因素模型结构，我们发现,在10年的随访中,只有惊恐障碍可使CAD风险显著增加1.1%(p值<0.001).
结论：焦虑症状，尤其是恐慌症，在10年的时间内，与发展CAD的总体风险增加独立且显着相关。因此,需要进一步的研究来研究焦虑可能导致CAD的机制，以及缓解这些过程的可能干预措施。
