关键词: Assisted Reproductive Technology (ART) Intracytoplasmic sperm injection (ICSI) Sperm Quality Assessment Sperm selection techniques

Mesh : Male Humans Reproductive Techniques, Assisted / trends Spermatozoa / physiology Female Pregnancy Sperm Injections, Intracytoplasmic / methods trends Sperm Motility / physiology Cell Separation / methods

来  源:   DOI:10.1186/s12958-024-01239-1   PDF(Pubmed)

Abstract:
This comprehensive review explores the evolving landscape of sperm selection techniques within the realm of Assisted Reproductive Technology (ART). Our analysis delves into a range of methods from traditional approaches like density gradient centrifugation to advanced techniques such as Magnetic-Activated Cell Sorting (MACS) and Intracytoplasmic Morphologically Selected Sperm Injection (IMSI). We critically assess the efficacy of these methods in terms of sperm motility, morphology, DNA integrity, and other functional attributes, providing a detailed comparison of their clinical outcomes. We highlight the transition from conventional sperm selection methods, which primarily focus on physical characteristics, to more sophisticated techniques that offer a comprehensive evaluation of sperm molecular properties. This shift not only promises enhanced prediction of fertilization success but also has significant implications for improving embryo quality and increasing the chances of live birth. By synthesizing various studies and research papers, we present an in-depth analysis of the predictability of different sperm selection procedures in ART. The review also discusses the clinical applicability of these methods, emphasizing their potential in shaping the future of assisted reproduction. Our findings suggest that the integration of advanced sperm selection strategies in ART could lead to more cost-effective treatments with reduced duration and higher success rates. This review aims to provide clinicians and researchers in reproductive medicine with comprehensive insights into the current state and future prospects of sperm selection technologies in ART.
摘要:
这篇全面的综述探讨了辅助生殖技术(ART)领域内精子选择技术的发展。我们的分析深入研究了一系列方法,从传统方法如密度梯度离心到先进技术,如磁激活细胞分选(MACS)和胞浆内形态选择精子注射(IMSI)。我们严格评估这些方法在精子运动性方面的功效,形态学,DNA完整性,和其他功能属性,提供了他们的临床结果的详细比较。我们强调了从传统精子选择方法的转变,主要关注物理特征,更复杂的技术,提供精子分子特性的全面评估。这种转变不仅有望增强对受精成功的预测,而且对提高胚胎质量和增加活产的机会具有重要意义。通过综合各种研究和研究论文,我们对ART中不同精子选择程序的可预测性进行了深入分析.该综述还讨论了这些方法的临床适用性,强调他们在塑造辅助生殖未来方面的潜力。我们的研究结果表明,在ART中整合先进的精子选择策略可以导致更具成本效益的治疗,缩短持续时间和更高的成功率。这篇综述旨在为生殖医学的临床医生和研究人员提供有关ART中精子选择技术的现状和未来前景的全面见解。
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