PDF(Pubmed)
Abstract：
Natural bioactives possess a wide range of chemical structures that can exert a plethora of pharmacological and toxicological actions, resulting in neuroprotection or neurotoxicity. These pharmacodynamic properties can positively or negatively impact human and animal global healthcare. Remarkably, Ayurvedic botanical Cannabis has been used worldwide by different ethnicities and religions for spiritual, commercial, recreational, nutraceutical, cosmeceutical, and medicinal purposes for centuries. Cannabis-based congeners have been approved by the United States of America\'s (USA) Food & Drug Administration (FDA) and other global law agencies for various therapeutic purposes. Surprisingly, the strict laws associated with possessing cannabis products have been mitigated in multiple states in the USA and across the globe for recreational use. This has consequently led to a radical escalation of exposure to cannabis-related substances of abuse. However, there is a lacuna in the literature on the acute and chronic effects of Cannabis and its congeners on various neuropathologies. Moreover, in the post-COVID era, there has been a drastic increase in the incidence and prevalence of numerous neuropathologies, leading to increased morbidity and mortality. There is an impending necessity for a safe, economically viable, multipotent, natural bioactive to prevent and treat various neuropathologies. The ayurvedic herb, Cannabis is one of the oldest botanicals known to humans and has been widely used. However, the comprehensive effect of Cannabis on various neuropathologies is not well established. Hence, this review presents effects of Cannabis on various neuropathologies.
摘要：
天然生物活性物质具有广泛的化学结构，可以发挥过多的药理和毒理学作用，导致神经保护或神经毒性。这些药效学特性可以积极或消极地影响人类和动物全球医疗保健。值得注意的是,阿育吠陀植物性大麻在世界范围内被不同种族和宗教用于精神，商业,休闲娱乐,营养食品，药妆，几个世纪以来的药用目的。基于大麻的同源物已被美国（美国）食品和药物管理局（FDA）和其他全球法律机构批准用于各种治疗目的。令人惊讶的是,与拥有大麻产品相关的严格法律已在美国和全球多个州得到缓解，用于娱乐用途。因此，这导致滥用大麻相关物质的接触急剧增加。然而,关于大麻及其同源物对各种神经病理学的急性和慢性影响的文献中存在空白。此外，在后COVID时代，许多神经病的发病率和患病率急剧增加，导致发病率和死亡率增加。有一个安全的迫在眉睫的必要性，经济上可行,多能，天然生物活性，以预防和治疗各种神经病变。阿育吠陀草药，大麻是人类已知的最古老的植物药之一，已被广泛使用。然而,大麻对各种神经病理学的综合作用尚未完全确定。因此，这篇综述介绍了大麻对各种神经病理的影响。
