Abstract：
Parabens have been used as antimicrobial preservatives since the 1920s. The prevalent use of parabens increases their detection in the environment and in women\'s biological samples including reproductive tissues. Recent studies suggest parabens may alter endocrine function and thus female reproductive health may be affected. In this literature review, we summarize findings on parabens and female reproduction while focusing on epidemiological and rodent-based studies. The topics reviewed include paraben effects on cyclicity, pregnancy, newborn and pubertal development, reproductive hormones, and ovarian and uterine specific outcomes. Overall, the scientific literature on paraben effects on female reproduction is limited and with some conflicting results. Yet, some epidemiological and/or rodent-based experimental studies report significant findings in relation to paraben effects on cyclicity, fertility, gestation length, birth weight, postnatal development and pubertal onset, hormone levels, and hormone signaling in reproductive tissues. Future epidemiological and experimental studies are needed to better understand paraben effects on female reproduction while focusing on human related exposures including mixtures, physiologic concentrations of parabens, and multi-generational studies.
摘要：
自1920年代以来，对羟基苯甲酸酯已被用作抗菌防腐剂。对羟基苯甲酸酯的普遍使用增加了它们在环境和包括生殖组织在内的妇女生物样品中的检测。最近的研究表明，对羟基苯甲酸酯可能会改变内分泌功能，因此女性生殖健康可能会受到影响。在这篇文献综述中，我们总结了对羟基苯甲酸酯和女性生殖的发现，同时重点关注流行病学和基于啮齿动物的研究。审查的主题包括对羟基苯甲酸酯对周期性的影响，怀孕,新生儿和青春期发育，生殖激素,卵巢和子宫特异性结局。总的来说,关于对羟基苯甲酸酯对女性生殖的影响的科学文献是有限的，并且有一些相互矛盾的结果。然而，一些流行病学和/或基于啮齿动物的实验研究报告了与对羟基苯甲酸酯对周期性影响有关的重大发现，生育力,妊娠长度，出生体重,出生后发育和青春期发作，激素水平,和生殖组织中的激素信号。未来的流行病学和实验研究需要更好地了解对羟基苯甲酸酯对女性生殖的影响，同时关注与人类相关的暴露，包括混合物。对羟基苯甲酸酯的生理浓度，和多代研究。
