电子传输链抑制增加了细胞对嘌呤传输和救助的依赖。
关键词: HPRT1 NAD(+):NADH ratio electron transport chain metabolomics purine metabolism stable isotopes
Mesh : Humans Purines / metabolism pharmacology Mitochondria / metabolism Electron Transport Hypoxanthine Phosphoribosyltransferase / metabolism genetics Pentose Phosphate Pathway Fibroblasts / metabolism Lung Neoplasms / metabolism pathology drug therapy Cell Line, Tumor Animals Biological Transport
来 源:
DOI:10.1016/j.cmet.2024.05.014
PDF(Pubmed)