PDF(Pubmed)
Abstract：
Magnesium Sulfate (MgSO4) is a widely used adjuvant in anesthesia. Often administered with local anesthetics, it is known to reduce analgesic and opioid consumption while extending the duration of analgesia. MgSO4 applications extend to orthopedic surgeries, cardiovascular and urogenital procedures, offering extended postoperative pain relief. While commonly administered through various routes, there is a research gap concerning the comparative efficacy of intrathecal (IT) and intravenous (IV) MgSO4 administration. This narrative review aims to provide a comparison between IT and IV administration of MgSO4 particularly following orthopedic procedures, where pain management is paramount. A comprehensive literature search was conducted across several electronic databases, trial registries, and gray literature from inception to 2023. Inclusion criteria encompassed studies investigating the effects of perioperative IT administration of magnesium compared to perioperative IV administration of MgSO4 in patients undergoing surgery, with no language restrictions. Our search identified 4326 articles, of which 9 randomized controlled trials met our inclusion criteria. We summarized these selected articles. Four studies discussed IT magnesium sulfate (MgSO4) administration, 2 focused on IT administration in orthopedic surgeries, and 3 explored both IV and IT administration of MgSO4 in orthopedic surgery. IT MgSO4 shows promise in postoperative pain management, delaying block onset and extending duration. Personalized administration choice, considering patient factors and surgery type, is crucial. Further research is needed to refine strategies for better patient outcomes, particularly following orthopedic surgeries.
摘要：
硫酸镁（MgSO4）是麻醉中广泛使用的佐剂。经常使用局部麻醉药，已知在延长镇痛持续时间的同时减少镇痛和阿片类药物的消耗。MgSO4应用扩展到骨科手术，心血管和泌尿生殖系统，提供延长术后疼痛缓解。虽然通常通过各种途径进行管理，关于鞘内（IT）和静脉（IV）MgSO4给药的比较疗效存在研究空白。这篇叙述性综述旨在提供IT和IV给药MgSO4之间的比较，特别是在骨科手术之后，疼痛管理至关重要。在几个电子数据库中进行了全面的文献检索，审判登记处，和灰色文学从成立到2023年。纳入标准包括研究在接受手术的患者中，围手术期IT施用镁与围手术期IV施用MgSO4相比的影响。没有语言限制。我们的搜索识别了4326篇文章，其中9项随机对照试验符合纳入标准.我们总结了这些精选的文章。四项研究讨论了IT硫酸镁（MgSO4）给药，2专注于骨科手术中的IT管理，3探索了骨科手术中MgSO4的IV和IT给药。ITMgSO4在术后疼痛管理中显示出希望，延迟阻滞发作和延长持续时间。个性化管理选择，考虑到患者因素和手术类型，至关重要。需要进一步的研究来完善策略，以获得更好的患者预后，尤其是在整形外科手术之后.
