PDF(Pubmed)
Abstract：
Postoperative ileus (POI) is a prevalent surgical complication, which results in prolonged hospitalization, patient distress, and substantial economic burden. The literature aims to present a brief outline of interventions for preventing and treating POI post-surgery. Data from 2014 to 2023 were gathered from reputable sources like PubMed, PubMed Central, Google Scholar, Research Gate, and Science Direct. Inclusion criteria focused on studies exploring innovative treatments and prevention strategies for POI, using keywords such as novel POI treatments, non-pharmacological prevention, POI incidence rates, POI management, and risk factors. The findings revealed that integration of preventive measures such as coffee consumption, chewing gum, probiotics, and use of dikenchuto within enhanced recovery programs has significantly reduced both the frequency and duration of POI, without any adverse effects, with minimally invasive surgical approaches showing promise as an additional preventive strategy. While treatment options such as alvimopan, NSAIDs, and acupuncture have demonstrated efficacy, the use of lidocaine has raised concerns due to associated adverse effects. The ongoing exploration of novel therapeutic strategies such as targeting the mast cells, vagal nerve stimulation and tight junction protein, and prokinetic-mediated instigation of the cholinergic anti-inflammatory trail not only holds promise for enhanced treatment but also deepens the understanding of intricate cellular and molecular pathways underlying POI. POI presents a complex challenge in various surgical specialties, necessitating a multifaceted management approach. The integration of preventive and treatment measures within enhanced recovery programs has significantly reduced POI frequency and duration.
摘要：
术后肠梗阻（POI）是一种常见的手术并发症，导致住院时间延长，病人的痛苦,和巨大的经济负担。文献旨在简要概述预防和治疗POI术后的干预措施。2014年至2023年的数据来自PubMed等知名来源，PubMedCentral,谷歌学者，研究门,科学直接。纳入标准侧重于探索POI的创新治疗和预防策略的研究，使用关键词，如新型POI治疗，非药物预防，POI发病率,POI管理,和风险因素。调查结果表明，咖啡消费等预防措施的整合，口香糖,益生菌，在增强恢复计划中使用dikenchuto显着降低了POI的频率和持续时间，没有任何不良影响，微创手术方法有望作为额外的预防策略。虽然治疗方案如alvimopan,NSAIDs,和针灸已经证明了疗效，由于相关的不良反应,利多卡因的使用引起了人们的关注.不断探索新的治疗策略，如靶向肥大细胞，迷走神经刺激和紧密连接蛋白，和促动力介导的胆碱能抗炎途径的激发不仅有望增强治疗，而且加深了对POI背后复杂的细胞和分子途径的理解。POI在各种外科专业中提出了复杂的挑战，需要多方面的管理方法。在增强的恢复计划中整合预防和治疗措施显着减少了POI的频率和持续时间。
