PDF(Pubmed)
Abstract：
It aims to study the efficacy and safety of low-concentration Atropine combined with orthokeratology (OK) lens in delaying juvenile myopia. This is a prospective study, 172 adolescents aged 8 to 12 years who were admitted to the diopter department of Hengshui People Hospital from April 2021 to May 2022 were selected. According to the equivalent spherical diopter measured at the time of initial diagnosis, myopic patients were randomly divided into low myopia group (group A) and moderate myopia group (group B). At the same time, according to the different treatment methods, the patients were divided into the group wearing frame glasses alone (group c), the group wearing frame glasses with low-concentration Atropine (group d), the group wearing corneal shaping glasses alone at night (group e), and the group wearing corneal shaping glasses at night with low-concentration Atropine (group f). The control effect of myopia development and axial elongation in group f was better than that in groups d and e (P < .05). The effect of controlling myopia development and axial elongation in group f is with P > .05. The probability of postoperative adverse reactions in group f was lower and lower than that in the other groups. Low-concentration atropine combined with OK lens could effectively delay the development of juvenile myopia, and had a high safety. Low-concentration of Atropine would not have a significant impact on the basic tear secretion and tear film stability. Nightwear of OK lens also had no significant impact, but it would significantly reduce the tear film rupture time in the first 3 months, and at the same time, the tear film rupture time would be the same after 6 months as before treatment.
摘要：
目的研究低浓度阿托品联合角膜塑形镜延缓青少年近视的疗效和安全性。这是一项前瞻性研究,选取2021年4月至2022年5月入住衡水市人民医院屈光度科的172名8~12岁青少年。根据初始诊断时测得的等效球面屈光度,将近视患者随机分为低度近视组(A组)和中度近视组(B组)。同时,根据不同的治疗方法，将患者分为仅戴框架眼镜的组（c组），戴低浓度阿托品镜框组（d组），晚上只戴角膜塑形眼镜的组(e组)，夜间配戴角膜塑形眼镜的组(f组)。f组近视发展和轴伸长的控制效果优于d、e组(P<0.05)。f组控制近视发育和眼轴伸长的效果P>.05。f组术后不良反应发生概率较低,且低于其他组。低浓度阿托品联合OK晶状体可有效延缓青少年近视的发展,而且安全性很高.低浓度的阿托品不会对基本泪液分泌和泪膜稳定性产生显著影响。OK镜头的睡衣也没有显著影响，但它会显著减少前3个月的泪膜破裂时间，同时,6个月后泪膜破裂时间与治疗前相同。
