PDF(Pubmed)
Abstract：
Waist-to-height ratio (WtHR) is a validated biomarker of central obesity that appears to be preferable to other body composition measurements in the evaluation of cardiovascular disease. The goal of this research was to explore the connection between WtHR and abdominal aortic calcification (AAC) among adults. On the basis of data from the 2013 to 2014 National Health and Nutrition Examination Survey, multivariate logistic regression, sensitivity analysis, as well as smoothed curve fitting were used to evaluate the connection between WtHR and AAC. Subgroup analyses along with interaction tests were done to see if this link was consistent across populations. Among 3079 participants aged >40 years, there was a negative association between WtHR and ACC. Each 1-unit emergence of WtHR was related to a 2% reduction in the probability of severe AAC in the entirely adjusted model (odds ratio = 0.02, 95% confidence interval: [0.00-0.12]). Participants in the highest WtHR quartile were 39% less likely to acquire severe AAC compared with those in the lowest quartile. (odds ratio = 0.61, 95% confidence interval: [0.37-1.00]). This negative association was more pronounced in the diabetes subgroup. We discovered a reversed U-shaped association between WtHR as well as AAC score utilizing a 2-stage linear regression model, with an intersection point of 0.56. WtHR was negatively associated with AAC among US adults.
摘要：
腰围与身高比（WtHR）是一种经过验证的中心性肥胖生物标志物，在评估心血管疾病时，它似乎比其他身体成分测量更可取。这项研究的目的是探讨WtHR与成人腹主动脉钙化（AAC）之间的联系。根据2013-2014年全国健康与营养调查数据，多元逻辑回归，敏感性分析，以及平滑曲线拟合用于评估WtHR和AAC之间的联系。进行了亚组分析以及相互作用测试，以查看这种联系在人群中是否一致。在3079名年龄>40岁的参与者中，WtHR与ACC呈负相关.在完全调整模型中，WtHR的每1个单位出现与严重AAC的概率降低2％有关（比值比=0.02，95％置信区间：[0.00-0.12]）。与最低四分位数的参与者相比，最高WtHR四分位数的参与者获得严重AAC的可能性降低了39％。(比值比=0.61，95%置信区间：[0.37-1.00])。这种负相关性在糖尿病亚组中更为明显。我们利用2阶段线性回归模型发现了WtHR和AAC得分之间的反向U形关联，交点为0.56。在美国成年人中，WTHR与AAC呈负相关。
