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Abstract：
BACKGROUND: A survey was conducted by The Harris Poll on behalf of Arcutis Biotherapeutics in the USA to understand perspectives and burden of patients with psoriasis using prescription topical treatments for their disease. This manuscript presents results from the subset of patients with intertriginous psoriasis.
METHODS: The survey was conducted online October 21-November 24, 2021, among 507 US adults aged 18+ years with psoriasis diagnosed by a healthcare provider and currently using prescription topical treatment. Participants with intertriginous psoriasis were patients with plaque psoriasis reporting symptoms in the armpit, groin, under breast, stomach fold, or between the buttocks.
RESULTS: Of the 507 respondents, 320 (64%) reported symptoms in intertriginous areas at some point, typically between the buttocks (31%). Most patients with intertriginous psoriasis reported it made them feel embarrassed (80%), anxious (79%), or depressed (69%). In addition, 45% of these patients reported intertriginous psoriasis caused a negative impact on sexual anxiety or distress. Quality of life impact was reported as \"very strong negative impact\" in 16% of patients with groin involvement vs. 6% in patients with no groin involvement and 15% in women vs. 6% in men. Patients with intertriginous psoriasis reported that itch (61%), scaling (53%), redness (49%), and skin cracking (46%) related to intertriginous psoriasis had the greatest negative impact on quality of life. Most (86%) of these patients said they would be more adherent if a single treatment option could be used to treat all affected areas of their body.
CONCLUSIONS: Psoriasis involvement in intertriginous areas over the course of disease is common and has a negative impact on these patients\' quality of life, particularly emotional well-being and sexual health.
METHODS: The survey was conducted online October 21-November 24, 2021, among 507 US adults aged 18+ years with psoriasis diagnosed by a healthcare provider and currently using prescription topical treatment. Participants with intertriginous psoriasis were patients with plaque psoriasis reporting symptoms in the armpit, groin, under breast, stomach fold, or between the buttocks.
RESULTS: Of the 507 respondents, 320 (64%) reported symptoms in intertriginous areas at some point, typically between the buttocks (31%). Most patients with intertriginous psoriasis reported it made them feel embarrassed (80%), anxious (79%), or depressed (69%). In addition, 45% of these patients reported intertriginous psoriasis caused a negative impact on sexual anxiety or distress. Quality of life impact was reported as \"very strong negative impact\" in 16% of patients with groin involvement vs. 6% in patients with no groin involvement and 15% in women vs. 6% in men. Patients with intertriginous psoriasis reported that itch (61%), scaling (53%), redness (49%), and skin cracking (46%) related to intertriginous psoriasis had the greatest negative impact on quality of life. Most (86%) of these patients said they would be more adherent if a single treatment option could be used to treat all affected areas of their body.
CONCLUSIONS: Psoriasis involvement in intertriginous areas over the course of disease is common and has a negative impact on these patients\' quality of life, particularly emotional well-being and sexual health.
摘要：
背景：HarrisPoll代表美国ArcutisBiotherapeutics进行了一项调查，以了解使用处方局部治疗的银屑病患者的观点和负担。该手稿提供了来自三性银屑病患者子集的结果。
方法：该调查于2021年10月21日至11月24日在线进行，调查对象为507名18岁以上的美国成年人，他们被医疗保健提供者诊断为牛皮癣，目前正在使用处方局部治疗。参与者间菌斑性银屑病患者报告的症状在腋下，腹股沟,乳房下,胃褶皱,或臀部之间。
结果：在507名受访者中，320（64％）在某个时候报告了在三间隙区域的症状，通常在臀部之间（31％）。大多数患者报告说，它使他们感到尴尬（80％），焦虑（79%），或抑郁（69%）。此外,这些患者中有45％报告了间质性牛皮癣对性焦虑或困扰产生了负面影响。生活质量影响报告为“非常强烈的负面影响”，在16％的腹股沟受累患者中，与没有腹股沟受累的患者为6％，女性为15％。6%的男性。间质性银屑病患者报告瘙痒（61%），缩放比例（53%），发红（49%），和皮肤开裂（46％）相关的三性银屑病对生活质量的负面影响最大。这些患者中的大多数（86％）表示，如果可以使用单一治疗方案来治疗身体的所有受影响区域，他们会更加坚持。
结论：银屑病在疾病的过程中在三间隙区受累是常见的，对这些患者的生活质量有负面影响，特别是情绪健康和性健康。
方法：该调查于2021年10月21日至11月24日在线进行，调查对象为507名18岁以上的美国成年人，他们被医疗保健提供者诊断为牛皮癣，目前正在使用处方局部治疗。参与者间菌斑性银屑病患者报告的症状在腋下，腹股沟,乳房下,胃褶皱,或臀部之间。
结果：在507名受访者中，320（64％）在某个时候报告了在三间隙区域的症状，通常在臀部之间（31％）。大多数患者报告说，它使他们感到尴尬（80％），焦虑（79%），或抑郁（69%）。此外,这些患者中有45％报告了间质性牛皮癣对性焦虑或困扰产生了负面影响。生活质量影响报告为“非常强烈的负面影响”，在16％的腹股沟受累患者中，与没有腹股沟受累的患者为6％，女性为15％。6%的男性。间质性银屑病患者报告瘙痒（61%），缩放比例（53%），发红（49%），和皮肤开裂（46％）相关的三性银屑病对生活质量的负面影响最大。这些患者中的大多数（86％）表示，如果可以使用单一治疗方案来治疗身体的所有受影响区域，他们会更加坚持。
结论：银屑病在疾病的过程中在三间隙区受累是常见的，对这些患者的生活质量有负面影响，特别是情绪健康和性健康。
