Abstract：
This chapter (part one of a trilogy) summarizes the neurobiological foundations of endogenous opioids in the regulation of energy balance and eating behavior, dysregulation of which translates to maladaptive dietary responses in individuals with obesity and eating disorders, including anorexia, bulimia, and binge eating disorder. Knowledge of these neurobiological foundations is vital to researchers\' and clinicians\' understanding of pathophysiology as well as the science-based development of multidisciplinary diagnoses and treatments for obesity and eating disorders. We highlight mechanisms of endogenous opioids in both homeostatic and hedonic feeding behavior, review research on the dysregulation of food reward that plays a role in a wide array of obesity and disordered eating, and the clinical implications of neurobiological responses to food for current science-based treatments for obesity and eating disorders.
摘要：
本章（三部曲的第一部分）总结了内源性阿片类药物在能量平衡和饮食行为调节中的神经生物学基础，在肥胖和饮食失调的个体中，失调会转化为适应不良的饮食反应，包括厌食症,贪食症,和暴饮暴食症。这些神经生物学基础的知识对于研究人员和临床医生对病理生理学的理解以及肥胖和饮食失调的多学科诊断和治疗的科学发展至关重要。我们强调内源性阿片类药物在稳态和享乐摄食行为中的机制，回顾关于在各种肥胖和饮食失调中起作用的食物奖励失调的研究，以及对食物的神经生物学反应对目前以科学为基础的肥胖和饮食失调治疗的临床意义。
