Abstract：
Phosphate is essential for numerous biological processes, and serum levels are tightly regulated to accomplish these functions. The regulation of serum phosphate in a narrow physiological range is a well-orchestrated process and involves the gastrointestinal (GI) tract, bone, kidneys, and several hormones, namely, parathyroid hormone, fibroblast growth factor 23 (FGF23), and 1,25-dihydroxyvitamin D (1,25 Vitamin D). Although primarily synthesized in the bone, FGF23, an endocrine FGF, acts on the kidney to regulate phosphate and Vitamin D homeostasis by causing phosphaturia and reduced levels of 1,25 Vitamin D. Recent studies have highlighted the complex regulation of FGF23 including transcriptional and post-translational modification and kidney-bone cross talk. Understanding FGF23 biology has led to the identification of novel therapeutic agents to treat diseases that disrupt phosphate metabolism secondary to FGF23. The focus of this review is to provide an overview of phosphate homeostasis, FGF23 biology, and the role of FGF23 in phosphate balance.
摘要：
磷酸盐是许多生物过程所必需的，和血清水平被严格调节以实现这些功能。在狭窄的生理范围内调节血清磷酸盐是一个精心策划的过程，涉及胃肠道（GI），骨头,肾脏，和几种荷尔蒙，即,甲状旁腺激素,成纤维细胞生长因子23（FGF23），和1,25-二羟维生素D（1,25维生素D）。虽然主要在骨骼中合成，FGF23，一种内分泌FGF，通过引起磷尿和1,25维生素D水平降低，对肾脏起作用以调节磷酸盐和维生素D的稳态。最近的研究强调了FGF23的复杂调节，包括转录和翻译后修饰以及肾骨串扰。对FGF23生物学的了解导致了新的治疗剂的鉴定，以治疗破坏FGF23继发的磷酸盐代谢的疾病。这篇综述的重点是提供磷酸盐稳态的概述，FGF23生物学，以及FGF23在磷酸盐平衡中的作用。
