METHODS: All elective surgeries performed at our neurosurgical department between 01/2018-08/2022 were investigated regarding the occurrence of VTE. The VTE risk and associated mortality were compared between groups: (1) only chemoprophylaxis (CHEMO; surgeries 01/2018-04/2020) and (2) IPC and chemoprophylaxis (IPC; surgeries 04/2020-08/2022). Furthermore, general patient and disease characteristics as well as duration of hospitalization were evaluated and compared to the VTE risk.
RESULTS: VTE occurred after 38 elective procedures among > 12.000 surgeries. The number of VTEs significantly differed between groups with an incidence of 31/6663 (0.47%) in the CHEMO group and 7/6688 (0.1%) events in the IPC group. In both groups, patients with malignant brain tumors represented the largest proportion of patients, while VTEs in benign tumors occurred only in the CHEMO group.
CONCLUSIONS: The use of combined mechanical and pharmacologic VTE prophylaxis can significantly reduce the risk of postoperative thromboembolism after neurosurgical procedures and, therefore, reduce mortality and morbidity.
方法:2018年01月至2022年08月在我们神经外科进行的所有择期手术均对VTE的发生进行了调查。比较两组之间的VTE风险和相关死亡率:(1)仅化学预防(CHEMO;手术01/2018-04/2020)和(2)IPC和化学预防(IPC;手术04/2020-08/2022)。此外,对患者的一般情况和疾病特征以及住院时间进行评估,并与VTE风险进行比较.
结果:在12.000例手术中,38例择期手术后发生了VTE。两组之间的VTE数量显着不同,CHEMO组的发生率为31/6663(0.47%),IPC组的发生率为7/6688(0.1%)。在这两组中,恶性脑肿瘤患者占患者比例最大,而良性肿瘤中的VTEs仅发生在CHEMO组。
结论:使用机械和药物联合预防VTE可以显着降低神经外科手术后血栓栓塞的风险,因此,降低死亡率和发病率。