Abstract：
Observational studies have suggested an association between metabolic syndrome (MetS) and hidradenitis suppurativa (HS), but whether this relationship is causal remains unclear. Elucidating the causal direction could provide insights into disease mechanisms and potential interventions. We performed bidirectional two-sample Mendelian randomization (MR) using summary statistics from genome-wide association studies (GWAS) of MetS and HS. For validation, we replicated the MetS analysis using data from an independent GWAS. We applied multiple MR methods, primarily inverse variance-weighted (IVW) regression, and conducted sensitivity analyses to assess heterogeneity and pleiotropy. The MR analysis demonstrated MetS causally increased HS risk (IVW odds ratio [OR], 1.428 [95% CI, 1.193-1.710]; p < 0.001), with consistent evidence from sensitivity analyses. However, HS did not appear to causally influence MetS risk (IVW OR, 1.008 [95% CI, 0.988-1.028]; p = 0.438). This study provides evidence that MetS causally increases the risk of developing HS. However, we found no evidence for a causal relationship in the reverse direction from HS to MetS. Further research is warranted to elucidate the mechanisms underlying the identified causal association between MetS and subsequent HS development.
摘要：
观察性研究表明，代谢综合征（MetS）和化脓性汗腺炎（HS）之间存在关联，但这种关系是否是因果关系尚不清楚.阐明因果方向可以提供对疾病机制和潜在干预措施的见解。我们使用MetS和HS的全基因组关联研究（GWAS）的汇总统计数据进行了双向双样本孟德尔随机化（MR）。对于验证，我们使用来自独立GWAS的数据复制了MetS分析。我们应用了多种MR方法，主要是逆方差加权(IVW)回归，并进行了敏感性分析，以评估异质性和多效性。MR分析显示MetS导致HS风险增加(IVW比值比[OR]，1.428[95%CI，1.193-1.710]；p<0.001)，具有来自敏感性分析的一致证据。然而,HS似乎没有因果关系影响MetS风险(IVW或，1.008[95%CI，0.988-1.028]；p=0.438）。这项研究提供了证据，表明MetS会增加患HS的风险。然而,我们没有发现从HS到MetS的反向因果关系的证据.需要进一步的研究来阐明MetS与随后的HS发展之间已确定的因果关联的潜在机制。
