PDF(Pubmed)
Abstract：
This review highlights recent advancements in the synthesis, processing, properties, and applications of 2D-material integrated hydrogels, with a focus on their performance in bone-related applications. Various synthesis methods and types of 2D nanomaterials, including graphene, graphene oxide, transition metal dichalcogenides, black phosphorus, and MXene are discussed, along with strategies for their incorporation into hydrogel matrices. These composite hydrogels exhibit tunable mechanical properties, high surface area, strong near-infrared (NIR) photon absorption and controlled release capabilities, making them suitable for a range of regeneration and therapeutic applications. In cancer therapy, 2D-material-based hydrogels show promise for photothermal and photodynamic therapies, and drug delivery (chemotherapy). The photothermal properties of these materials enable selective tumor ablation upon NIR irradiation, while their high drug-loading capacity facilitates targeted and controlled release of chemotherapeutic agents. Additionally, 2D-materials -infused hydrogels exhibit potent antibacterial activity, making them effective against multidrug-resistant infections and disruption of biofilm generated on implant surface. Moreover, their synergistic therapy approach combines multiple treatment modalities such as photothermal, chemo, and immunotherapy to enhance therapeutic outcomes. In bio-imaging, these materials serve as versatile contrast agents and imaging probes, enabling their real-time monitoring during tumor imaging. Furthermore, in bone regeneration, most 2D-materials incorporated hydrogels promote osteogenesis and tissue regeneration, offering potential solutions for bone defects repair. Overall, the integration of 2D materials into hydrogels presents a promising platform for developing multifunctional theragenerative biomaterials.
摘要：
这篇综述强调了合成方面的最新进展，processing,属性,二维材料集成水凝胶的应用，专注于它们在骨骼相关应用中的表现。二维纳米材料的各种合成方法和类型，包括石墨烯，氧化石墨烯,过渡金属二硫属化物，黑磷,讨论了MXene，以及它们掺入水凝胶基质的策略。这些复合水凝胶表现出可调的机械性能，高表面积,强的近红外（NIR）光子吸收和控制释放能力，使它们适用于一系列的再生和治疗应用。在癌症治疗中，基于2D材料的水凝胶有望用于光热和光动力治疗，和药物递送（化疗）。这些材料的光热特性能够在NIR照射下选择性消融肿瘤，而它们的高载药能力有利于化疗剂的靶向和控释。此外,2D材料注入的水凝胶表现出有效的抗菌活性，使它们有效对抗多药耐药感染和破坏植入物表面产生的生物膜。此外，他们的协同治疗方法结合了多种治疗方式，如光热，化疗,和免疫疗法，以提高治疗效果。在生物成像中，这些材料用作多功能造影剂和成像探针，在肿瘤成像过程中实现实时监测。此外，在骨骼再生中，大多数2D材料掺入的水凝胶促进成骨和组织再生，提供骨缺损修复的潜在解决方案。总的来说,将二维材料整合到水凝胶中，为开发多功能热能量生物材料提供了一个有前途的平台。
